Aging, defined as degeneration in locomotory and physiological performances, initiates from the completion of post-natal growth to the death of organisms. A significant burden can be incurred economically and medically when aging, which leads us to seek an understanding of the underlying mechanisms and ways to reduce or retard aging-related disorders such as sarcopenia, osteoporosis, osteoarthritis, and metabolic syndromes, neurological disorders, and even cancers. Current evidence shows that aging is closely related to mitochondrial dysfunction, loss of proteostasis, changes in gut microbiota, et al., and these factors increase inflammation. Therefore, therapeutics participating in the immune response are increasingly investigated to retard aging and related disorders.
Since aging and related disorders have various manifestations at cellular, proteomic, transcriptional levels, integrative analysis is vital in identifying targets. This Research Topic aims to study the underlying mechanisms of aging and related disorders with specific attention to molecular targets with immune-regulatory potential. Through bioinformatics analysis and/or basic experiments, novel molecules can be screened and tested. On the ground of this, this topic welcomes research on developing, screening, analyzing, or testing new agents with immune-regulatory effects to treat aging and related disorders, such as diabetes, sarcopenia, and cancers.
In this Research Topic, we welcome original papers, reviews, letters, and systematic reviews, including but not limited to:
• Mechanisms and targets identification of aging and related disorders, including cancers;
• Application of immune-regulatory agents in aging and related disorders in clinics;
• Discovery of novel targets with immune-regulatory effects against aging and related disorders;
• Translational research of novel targets to regulate the immune response in aging and related disorders;
• Genome-wide association or network pharmacology approach to identify a novel link between medications and diseases in aging and related disorders.
Original research based solely on in silico techniques will not be considered for review.
Aging, defined as degeneration in locomotory and physiological performances, initiates from the completion of post-natal growth to the death of organisms. A significant burden can be incurred economically and medically when aging, which leads us to seek an understanding of the underlying mechanisms and ways to reduce or retard aging-related disorders such as sarcopenia, osteoporosis, osteoarthritis, and metabolic syndromes, neurological disorders, and even cancers. Current evidence shows that aging is closely related to mitochondrial dysfunction, loss of proteostasis, changes in gut microbiota, et al., and these factors increase inflammation. Therefore, therapeutics participating in the immune response are increasingly investigated to retard aging and related disorders.
Since aging and related disorders have various manifestations at cellular, proteomic, transcriptional levels, integrative analysis is vital in identifying targets. This Research Topic aims to study the underlying mechanisms of aging and related disorders with specific attention to molecular targets with immune-regulatory potential. Through bioinformatics analysis and/or basic experiments, novel molecules can be screened and tested. On the ground of this, this topic welcomes research on developing, screening, analyzing, or testing new agents with immune-regulatory effects to treat aging and related disorders, such as diabetes, sarcopenia, and cancers.
In this Research Topic, we welcome original papers, reviews, letters, and systematic reviews, including but not limited to:
• Mechanisms and targets identification of aging and related disorders, including cancers;
• Application of immune-regulatory agents in aging and related disorders in clinics;
• Discovery of novel targets with immune-regulatory effects against aging and related disorders;
• Translational research of novel targets to regulate the immune response in aging and related disorders;
• Genome-wide association or network pharmacology approach to identify a novel link between medications and diseases in aging and related disorders.
Original research based solely on in silico techniques will not be considered for review.
