About this Research Topic

Abstract Submission Deadline 31 October 2022
Manuscript Submission Deadline 15 January 2023

Central nervous system (CNS) disorders are defined as any condition causing brain disturbances or dysfunctions, including but not limited to stroke, neurodegeneration, neuropsychiatric disorders, and seizures. Although the basic therapeutic targets differ, the successful treatments for CNS disorders are all ...

Central nervous system (CNS) disorders are defined as any condition causing brain disturbances or dysfunctions, including but not limited to stroke, neurodegeneration, neuropsychiatric disorders, and seizures. Although the basic therapeutic targets differ, the successful treatments for CNS disorders are all challenged by the sophisticated brain function network. The biological events are so strictly controlled in neuronal cells that over-activation or -inhibition of one molecular target may result in lethal side effects. Moreover, CNS disorders usually undergo a long-term pathological process during which the role of a signaling pathway may change over time. What makes the situation more complicated is the remarkable spatial heterogeneity in molecular expression and function. Taken all, a highly temporally and spatially restricted illustration of the pathological process of CNS disorders is undoubtedly critical and urgent for the development of novel therapeutic strategies for CNS disorders.

In the past few decades, technical advancement has realized the superior spatiotemporal resolution of detection and even manipulation of biological events. Researchers now have equipped with hundreds of precise probes for real-time monitoring of endogenous molecules and have been able to deplete a gene of interest in a certain cell type, optically control the activity of targeted proteins, choose a programmed cell death mechanism for an individual cell, and analyze the entire genomes of a brain region at a single-cell resolution, all of which sharpen our understanding of spatiotemporal regulation of central nervous system disorders. The goal of this Research Topic is to bring together a collection of papers that discuss molecular mechanisms underlying spatially and/or temporally specific regulation strategies in the context of CNS disorders. In addition, we invite informative papers discussing cutting-edge techniques which will further improve the spatiotemporal resolution of the details of CNS disorders.

Topics include but are not limited to:
• Spatial transcriptome and its application in CNS disorders
• Single-cell-sequencing and cell-type diversity in CNS disorders
• Differential regulation of cell death pathways in different types of cells
• Functional switch of neuroinflammation mediators during CNS disorders
• Region-restricted regulatory mechanisms of synaptic plasticity or neuronal excitability
• Molecular basis of the neural circuit reorganization under pathological conditions
• Spatiotemporal evolution of the pathological process in the brain
• Cell-type-specific role of a particular molecule in CNS disorders
• Key biological events in the different stages of CNS disorders
• Potential targets for the precise treatment of CNS disorders

Keywords: central nervous system disorders, spatiotemporal regulation, molecular mechanisms, transcriptome, single-cell resolution


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