In many cancers and in particular in lung and colorectal cancers, the discovery and understanding of the biological functions of oncoproteins were beneficial for developing highly efficient target-based drugs. The exploration of molecular mechanisms of oncoproteins regarding their effects on tumor growth and metastasis also led to new insights on the drivers of cancer progression.
By analyzing the interaction regions of oncoproteins and their binding proteins, new anticancer drugs including polypeptides can be designed. Although numerous pathways have been investigated, the interactome of numerous oncoproteins is still largely unknown. It can therefore be proposed that new targets can still be discovered by studying oncoproteins and their molecular partners, and new drugs could result from these investigations. These drugs can be conventional chemical compounds but also polypeptides. In the latter case, nanoparticles and/or liposomes may be particularly suited to increase efficacy while reducing toxicity.
Scope of the Research Topic:
• Molecular characterization of newly discovered targets in lung and colorectal cancers
• Design and synthesis of polypeptides or compounds targeting oncoproteins and/or interacting proteins in lung and colorectal cancers
• Optimization of new targeted therapies to treat lung and colon cancers using nanomaterials
In many cancers and in particular in lung and colorectal cancers, the discovery and understanding of the biological functions of oncoproteins were beneficial for developing highly efficient target-based drugs. The exploration of molecular mechanisms of oncoproteins regarding their effects on tumor growth and metastasis also led to new insights on the drivers of cancer progression.
By analyzing the interaction regions of oncoproteins and their binding proteins, new anticancer drugs including polypeptides can be designed. Although numerous pathways have been investigated, the interactome of numerous oncoproteins is still largely unknown. It can therefore be proposed that new targets can still be discovered by studying oncoproteins and their molecular partners, and new drugs could result from these investigations. These drugs can be conventional chemical compounds but also polypeptides. In the latter case, nanoparticles and/or liposomes may be particularly suited to increase efficacy while reducing toxicity.
Scope of the Research Topic:
• Molecular characterization of newly discovered targets in lung and colorectal cancers
• Design and synthesis of polypeptides or compounds targeting oncoproteins and/or interacting proteins in lung and colorectal cancers
• Optimization of new targeted therapies to treat lung and colon cancers using nanomaterials
