About this Research Topic
Advances in comprehensive multi-omic molecular profiling, tumor classification, early diagnosis, and prognostication have led to reductions in overall cancer mortality. Epigenomic modifications connect biological and social determinants of health and have been proposed as a contributor to cancer disparities. By regulating gene expression at multiple levels (i.e., transcriptional, post-transcriptional, translational, and posttranslational), epigenomic modifications can affect various biological processes that regulate cancer development and progression. However, there are limited studies on epigenomic profiling in ethnically diverse populations, leading to a poor understanding of the intrinsic characteristics of the tumors’ epigenome in minority populations. Comprehensive profiling and characterization of the epigenome of tumors from ethnically diverse populations are needed to better understand the role of biological, genetic, social, and environmental determinants of cancer health disparities.
The aim of this Research Topic is to highlight studies on the role of epigenomic deregulation, whether isolated or in association with environmental and social determinants (e.g. built environment, physical environment, air/water pollution, neighborhood disadvantage, socioeconomic status, income, education, structural racism, discrimination, etc), in cancer disparities in minority and ethnic populations. Specific topics include but are not limited to:
- epigenetic modifications, DNA methylation, histone modifications, and non-coding RNAs (e.g., miRNAs, long non-coding RNAs).
- Fundamental science (e.g. in vitro and in vivo tumor models) and clinical studies (e.g., tumor tissues and liquid biopsy samples) will be considered. Studies can involve early or late-life exposure and any environmental-exposed population.
We welcome original studies, review articles, and articles on the current challenges and limitations (e.g., study design, population access, sample availability, ethical considerations, experimental methods, data analysis) of conducting social epigenomics studies and recommendations on how to overcome these limitations. Ancestral marker analysis characterization of the patients, whenever possible, is advisable, especially in highly admixed populations, such as Latinas/Hispanics.
Please note: manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
Keywords: Cancer health disparities, Minority (diverse) populations, Epigenomic diversity, Social epigenomics, Epigenomic deregulation, Epigenomic profiling
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.