About this Research Topic
It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against ubiquitous pathogens, communicate in a very organized fashion with the brain to regulate a set of physiological behaviours. Perturbing this immune to brain communication for instance in the case of bacterial/viral infection can cause long-term alterations in immune and neuronal (spinal and supraspinal) responses, leading to altered behavioural and psychological disorders (i.e. increased pain sensitivity, altered emotional responses, autism etc...) later in life.
How neonatal and adult inflammatory challenge can lead to altered immune and neuronal responses and which immune cells both at the periphery and the central nervous system contribute to this neuroinflammation is the aim of this topic. A big focus will be dedicated to the role of neuroimmune interface in health and disease (with particular focus on pain).
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