The bone is important for supporting body movement. However, the number of bone injuries caused by tumor disease, trauma, and osteoporosis is increasing dramatically every year. All of these orthopedic diseases can have serious health consequences, and bone metastasis is the most predominant complication of malignant tumors. In tumor bone metastasis, the bone represents “an airport hub” of cancer cells deriving from different types of primary tumors. Interactions taking place in this microenvironment can determine the cell fate impacting the clinical outcomes of the cancer disease. Alterations to the bone homeostasis can particularly favor tumor homing and consequent osteolytic or osteoblastic lesions. When tumor cells established in the bone microenvironment by disrupting the bone homeostasis, it will result in increased bone destruction (osteoclast) and/or bone formation (osteoblast). Overall, tumor cells interact with bone and bone marrow cells, disrupting bone homeostasis and driving tumor growth. This process of bone remodeling increases the risk of fractures and causes severe bone pain. Since then, studying bone homeostasis and how it relates to tumor bone metastasis will allow researchers to identify future directions in orthopedic disease research.
The purpose of this research topic is to provide a platform for researchers who work on orthopaedics, cancer and metastasis to investigate the pathological mechanism of tumor bone metastasis caused by interruption of the homeostasis of the bone microenvironment by tumor cells. We wish to elucidate the potential roles and regulatory mechanisms of the complex crosstalk between tumor cells and the bone microenvironment. Further, we hope this Research Topic can open our minds to exploring underlying mechanisms of bone homeostasis in other orthopedic diseases.
This Research Topic aims to gather Original Research, Review, Mini-Review, Focused Review, Protocol, Method, Perspective, and Opinion articles concerning the following subtopics, including but not limited to:
• Role of tumor cells in regulating bone homeostasis imbalance as well as the relationship between tumor bone metastasis and bone homeostasis imbalance;
• Identifying prevention strategies and targets for tumor bone metastasis;
• Bioinformatical analysis of the underlying mechanisms related to tumor bone metastasis, including but not limited to differential gene or non-coding RNAs expression, Go and KEGG pathway enrichment analysis, and module analyses for protein-protein interaction (PPI) network;
• Relationship between the immune system and tumor cells in the bone microenvironment;
• Genes or non-coding RNAs mediate tumor bone metastasis by regulating bone homeostasis in the bone microenvironment;
• The mechanisms of bone homeostasis imbalance caused by tumor cells extend to the occurrence and progression of other orthopaedic diseases
The bone is important for supporting body movement. However, the number of bone injuries caused by tumor disease, trauma, and osteoporosis is increasing dramatically every year. All of these orthopedic diseases can have serious health consequences, and bone metastasis is the most predominant complication of malignant tumors. In tumor bone metastasis, the bone represents “an airport hub” of cancer cells deriving from different types of primary tumors. Interactions taking place in this microenvironment can determine the cell fate impacting the clinical outcomes of the cancer disease. Alterations to the bone homeostasis can particularly favor tumor homing and consequent osteolytic or osteoblastic lesions. When tumor cells established in the bone microenvironment by disrupting the bone homeostasis, it will result in increased bone destruction (osteoclast) and/or bone formation (osteoblast). Overall, tumor cells interact with bone and bone marrow cells, disrupting bone homeostasis and driving tumor growth. This process of bone remodeling increases the risk of fractures and causes severe bone pain. Since then, studying bone homeostasis and how it relates to tumor bone metastasis will allow researchers to identify future directions in orthopedic disease research.
The purpose of this research topic is to provide a platform for researchers who work on orthopaedics, cancer and metastasis to investigate the pathological mechanism of tumor bone metastasis caused by interruption of the homeostasis of the bone microenvironment by tumor cells. We wish to elucidate the potential roles and regulatory mechanisms of the complex crosstalk between tumor cells and the bone microenvironment. Further, we hope this Research Topic can open our minds to exploring underlying mechanisms of bone homeostasis in other orthopedic diseases.
This Research Topic aims to gather Original Research, Review, Mini-Review, Focused Review, Protocol, Method, Perspective, and Opinion articles concerning the following subtopics, including but not limited to:
• Role of tumor cells in regulating bone homeostasis imbalance as well as the relationship between tumor bone metastasis and bone homeostasis imbalance;
• Identifying prevention strategies and targets for tumor bone metastasis;
• Bioinformatical analysis of the underlying mechanisms related to tumor bone metastasis, including but not limited to differential gene or non-coding RNAs expression, Go and KEGG pathway enrichment analysis, and module analyses for protein-protein interaction (PPI) network;
• Relationship between the immune system and tumor cells in the bone microenvironment;
• Genes or non-coding RNAs mediate tumor bone metastasis by regulating bone homeostasis in the bone microenvironment;
• The mechanisms of bone homeostasis imbalance caused by tumor cells extend to the occurrence and progression of other orthopaedic diseases
