The rapid outbreak of diabetes mellitus (DM) continues to be one of the largest public health problems around the globe, leading to reduced quality of life and higher premature mortality. However, drugs for the effective treatment of DM and its complications are limited. Comprehensive and in-depth revealing molecular mechanism of DM is essential for discovering novel treatment methods. At present, dysfunctional autophagy and hypoxia induction factors (HIF) of tissues and organs in DM have attracted much attention from researchers. Autophagy is the major intracellular degradation system that serves as a dynamic recycling system for cellular renovation and homeostasis. Dysfunctional autophagy contributes to many diseases, including diabetes and its complications. Meanwhile, hypoxia is considered an important pathological factor for multi-organ damage in DM. Abnormal HIFs are the key links that mediate multi-organ damage caused by hypoxia such as heart and kidneys. Noteworthy, there is a crosstalk between autophagy and HIF signaling pathways. Therefore, it is necessary to clarify the regulatory network between autophagy and HIF, and further study the difference between organs and tissues, thereby providing new ideas for the treatment of DM and its complications.
This Research Topic aims to create a forum for new insights into understanding the role of autophagy and HIFs in DM and its complication, as well as the potential regulatory network between autophagy and HIF signaling pathways.
We welcome submissions of Original research articles, Review articles, Opinions and Perspectives regarding the following subtopics, including but not limited to:
• Autophagy related pathogenesis of DM and its complications;
• Lysosomal dysfunction related pathogenesis of DM and its complications;
• Hypoxia and HIFs related pathogenesis of DM and its complications;
• Crosstalk between autophagy and HIF signaling pathways in DM and its complications;
• Novel therapeutics agents to improve DM and its complications based on autophagy and HIF signaling pathways.
The rapid outbreak of diabetes mellitus (DM) continues to be one of the largest public health problems around the globe, leading to reduced quality of life and higher premature mortality. However, drugs for the effective treatment of DM and its complications are limited. Comprehensive and in-depth revealing molecular mechanism of DM is essential for discovering novel treatment methods. At present, dysfunctional autophagy and hypoxia induction factors (HIF) of tissues and organs in DM have attracted much attention from researchers. Autophagy is the major intracellular degradation system that serves as a dynamic recycling system for cellular renovation and homeostasis. Dysfunctional autophagy contributes to many diseases, including diabetes and its complications. Meanwhile, hypoxia is considered an important pathological factor for multi-organ damage in DM. Abnormal HIFs are the key links that mediate multi-organ damage caused by hypoxia such as heart and kidneys. Noteworthy, there is a crosstalk between autophagy and HIF signaling pathways. Therefore, it is necessary to clarify the regulatory network between autophagy and HIF, and further study the difference between organs and tissues, thereby providing new ideas for the treatment of DM and its complications.
This Research Topic aims to create a forum for new insights into understanding the role of autophagy and HIFs in DM and its complication, as well as the potential regulatory network between autophagy and HIF signaling pathways.
We welcome submissions of Original research articles, Review articles, Opinions and Perspectives regarding the following subtopics, including but not limited to:
• Autophagy related pathogenesis of DM and its complications;
• Lysosomal dysfunction related pathogenesis of DM and its complications;
• Hypoxia and HIFs related pathogenesis of DM and its complications;
• Crosstalk between autophagy and HIF signaling pathways in DM and its complications;
• Novel therapeutics agents to improve DM and its complications based on autophagy and HIF signaling pathways.
