About this Research Topic
Circadian rhythms allow us to adapt to the changes of day and night in the span of 24 hours, modulating energy metabolism, inflammatory processes, cellular renewal, and even the interplay with the gut microbiota.
In mammals, the central clock is located in the suprachiasmatic nucleus (SCN) of the hypothalamus, which receives light cues. Along with the brain, the circadian clock functions in peripheral organs, including the liver, fat, and muscle. These local or peripheral clocks are semi-autonomous elements of a larger system and are synchronized by the SCN clock, functioning as an “orchestra director,” via neural, humoral, and behavioural inputs.
Disruption of circadian rhythms owing to jet lag, time shift work, and irregular meal timing has been linked to metabolic diseases. These observations suggest that the circadian clock controls several signalling pathways encompassing major components of metabolic homeostasis.
For this reason, understanding the ties between metabolism and the circadian clock will provide not only needed insights about circadian physiology, but also novel approaches regarding pharmacological and nonpharmacological treatment of metabolic disorders.
The current Research Topic encourages original research, reviews, or other accepted article types relating, but not limited, to:
- Recent advances in profiling of circadian rhythms: signal processing, mathematical and statistical modelling.
- Recent advances in profiling of circadian rhythms: technology, algorithms and machine learning, deep learning, and visualization tools.
- Circadian regulation of mitochondrial function and morphology.
- Genetic, epigenetic, and transcriptional signature of circadian rhythms in metabolic and endocrine diseases.
- Metabolomic and lipidomics-based approaches for circadian rhythms.
- Time-restricted eating in health and disease.
- Chronopharmacology for managing metabolic and endocrine diseases.
In mammals, the central clock is located in the suprachiasmatic nucleus (SCN) of the hypothalamus, which receives light cues. Along with the brain, the circadian clock functions in peripheral organs, including the liver, fat, and muscle. These local or peripheral clocks are semi-autonomous elements of a larger system and are synchronized by the SCN clock, functioning as an “orchestra director,” via neural, humoral, and behavioural inputs.
Disruption of circadian rhythms owing to jet lag, time shift work, and irregular meal timing has been linked to metabolic diseases. These observations suggest that the circadian clock controls several signalling pathways encompassing major components of metabolic homeostasis.
For this reason, understanding the ties between metabolism and the circadian clock will provide not only needed insights about circadian physiology, but also novel approaches regarding pharmacological and nonpharmacological treatment of metabolic disorders.
The current Research Topic encourages original research, reviews, or other accepted article types relating, but not limited, to:
- Recent advances in profiling of circadian rhythms: signal processing, mathematical and statistical modelling.
- Recent advances in profiling of circadian rhythms: technology, algorithms and machine learning, deep learning, and visualization tools.
- Circadian regulation of mitochondrial function and morphology.
- Genetic, epigenetic, and transcriptional signature of circadian rhythms in metabolic and endocrine diseases.
- Metabolomic and lipidomics-based approaches for circadian rhythms.
- Time-restricted eating in health and disease.
- Chronopharmacology for managing metabolic and endocrine diseases.
Keywords: Circadian rhythm; omics; mathematical modeling; metabolism
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