Bladder cancer is one of the most common cancers worldwide and one of the most prevalent genitourinary cancers. Bladder cancer is a heterogenous disease classified into two sub-types, non-muscle invasive bladder cancer (NMIBC) which accounts for approximately 75% of bladder cancer cases and the remaining 25% have muscle-invasive bladder cancer (MIBC). Although there has been development in the field of treatment and therapeutic approaches for bladder cancer patients, the survival rate and prognosis remain very poor and there is a high recurrence risk associated with the disease. Further studies are required to deepen our understanding of molecular mechanisms which impact bladder cancer and to identify novel targets and therapeutic alternatives for early detection and effective treatment.
Tumor progression is a very complex process which involves interactions between the tumor and its environment. The tumor microenvironment (TME) is primarily composed of tumor cells, vascular network, extracellular matrix and tumor-infiltrating immune cells, in addition to association with oncogenes and tumor suppressors. These have all been demonstrated to impact tumor progression and the metastasis of malignancies. Tumor-infiltrating immune cells have been found to be closely associated with clinical outcomes and can influence tumor progression. Bladder cancer is characterized by highly immunosuppressive and pro-inflammatory TME. Studies have found that tumor-associated macrophages display pro-tumoral effects via interaction with cancer-associated fibroblasts, cancer cells, regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), tumor stroma and extracellular matrix. Further research is required to understand how the TME mechanisms regulate tumor progression and development.
This Research Topic explores how the tumor microenvironment impacts bladder cancer patients and the molecular mechanisms which have an influence on tumor progression. We welcome Original Research, Reviews, Systematic Reviews and Mini-Reviews.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Bladder cancer is one of the most common cancers worldwide and one of the most prevalent genitourinary cancers. Bladder cancer is a heterogenous disease classified into two sub-types, non-muscle invasive bladder cancer (NMIBC) which accounts for approximately 75% of bladder cancer cases and the remaining 25% have muscle-invasive bladder cancer (MIBC). Although there has been development in the field of treatment and therapeutic approaches for bladder cancer patients, the survival rate and prognosis remain very poor and there is a high recurrence risk associated with the disease. Further studies are required to deepen our understanding of molecular mechanisms which impact bladder cancer and to identify novel targets and therapeutic alternatives for early detection and effective treatment.
Tumor progression is a very complex process which involves interactions between the tumor and its environment. The tumor microenvironment (TME) is primarily composed of tumor cells, vascular network, extracellular matrix and tumor-infiltrating immune cells, in addition to association with oncogenes and tumor suppressors. These have all been demonstrated to impact tumor progression and the metastasis of malignancies. Tumor-infiltrating immune cells have been found to be closely associated with clinical outcomes and can influence tumor progression. Bladder cancer is characterized by highly immunosuppressive and pro-inflammatory TME. Studies have found that tumor-associated macrophages display pro-tumoral effects via interaction with cancer-associated fibroblasts, cancer cells, regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), tumor stroma and extracellular matrix. Further research is required to understand how the TME mechanisms regulate tumor progression and development.
This Research Topic explores how the tumor microenvironment impacts bladder cancer patients and the molecular mechanisms which have an influence on tumor progression. We welcome Original Research, Reviews, Systematic Reviews and Mini-Reviews.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
