About this Research Topic
In this Research Topic, we seek to collect the most recent insights from the emerging field of noncoding RNAs in a neurodegenerative context. We are especially focused on the potential involvement of specific ncRNAs in the major neurodegenerative disorders – AD, PD, HD and ALS. However, we wil also consider studies from other neuropathological fields, including those from rare diseases. Importantly, we aim to integrate new ideas, concepts, and disease models, to garner a better understanding of ncRNAs dysregulation in neurodegeneration-associated mechanisms. We are also interested in exploiting the potential application of ncRNAs as diagnostic/prognosis non-invasive biomarkers, and to decipher their value as disease-modifying targets. Moreover, we would like to explore the role of extracellular vesicles as ncRNA delivering systems between different cell types (e.g., neurons and microglia), and discuss their use in future neuropharmacological strategies.
In this Research Topic, we welcome original research manuscripts, perspectives and reviews covering the following areas:
- The role of ncRNAs in AD, PD, HD, ALS as well as in other neurodegenerative diseases
- Advanced in vitro cell modeling (e.g., stem cells, iPSC-derived cells, 3D organoids) to study ncRNA signaling
- In vivo studies addressing ncRNA dynamics, homeostasis, intercellular communication, and neurocognitive effects
- Single-cell RNA sequencing data focusing ncRNAs and their targets
- Circulating fluid / extracellular vesicle -associated ncRNAs and their pathophysiology in neurodegenerative context
- Candidate ncRNAs that may constitute either good biomarkers or therapeutic targets for neurodegeneration
- Integrative and/or conceptual studies concerning ncRNAs in brain (dys)function including potential neuropharmacological strategies
- Involvement of ncRNAs in neuron-glia communication, neuroinflammation and synapse (dys)function
Keywords: MicroRNAs, Long-NoncodingRNAs, Cell Reprograming, Small Extracellular Vesicles (Exosomes), Neuron-Glia Dynamics, Personalized Biomedicine, Non-Invasive Biomarkers, Neuronal (Dys)Function, Neuroinflammation, Neurodegeneration
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.