Gastrointestinal (GI) malignancies, which mainly include stomach, liver, pancreas, small intestine, colon, and rectal cancers, are the major causes of cancer-related death worldwide. Surgery, radiotherapy, chemotherapy, irreversible electroporation, cryotherapy, molecular targeted therapy, immunity therapy, etc., have been the main treatment methods for GI malignancies in recent years. However, many patients with GI malignancies are diagnosed at the late stage of the disease, which limits the treatment efficacy and shortens their survival time. Therefore, it is important and necessary to find other promising treatment methods for the treatment of GI malignancies.
Natural product extracts (NPE), derived from various natural sources such as medicinal plants, marine organisms, vegetables and fruits, play an increasingly important role in the therapy of various chronic diseases such as gastrointestinal cancer. NPE has shown the potential to reduce the risk of cancer and slow its progression. Many naturally occurring secondary metabolites have been shown to exhibit chemo-preventive properties when tested in cell lines or animal models. However, the wide variety of active metabolites of plant origin, including polyphenols, terpenes, alkaloids or sulfur compounds, emphasize the omnidirectional nature of natural products. Therefore, a systemic study needs to be present in the therapy of the anticancer effect of NPE, or even side effects of NPE.
When authors submit manuscripts for this Research Topic, research articles, reviews or mini-review articles are acceptable. The themes of the articles include but are not limited to:
• Developing new NPE from various natural sources and studying their treatment efficacy towards GI malignancies.
• Investigating the specific active components of NPE for cancer prevention.
• To clarify the antitumor mechanism and safety of NPE.
• Investigating the synergistic effect of NPE and chemotherapeutic agents for GI cancers.
• Summarizing the treatment efficacy, mechanism, and safety of specific NPE for GI cancer treatment
Gastrointestinal (GI) malignancies, which mainly include stomach, liver, pancreas, small intestine, colon, and rectal cancers, are the major causes of cancer-related death worldwide. Surgery, radiotherapy, chemotherapy, irreversible electroporation, cryotherapy, molecular targeted therapy, immunity therapy, etc., have been the main treatment methods for GI malignancies in recent years. However, many patients with GI malignancies are diagnosed at the late stage of the disease, which limits the treatment efficacy and shortens their survival time. Therefore, it is important and necessary to find other promising treatment methods for the treatment of GI malignancies.
Natural product extracts (NPE), derived from various natural sources such as medicinal plants, marine organisms, vegetables and fruits, play an increasingly important role in the therapy of various chronic diseases such as gastrointestinal cancer. NPE has shown the potential to reduce the risk of cancer and slow its progression. Many naturally occurring secondary metabolites have been shown to exhibit chemo-preventive properties when tested in cell lines or animal models. However, the wide variety of active metabolites of plant origin, including polyphenols, terpenes, alkaloids or sulfur compounds, emphasize the omnidirectional nature of natural products. Therefore, a systemic study needs to be present in the therapy of the anticancer effect of NPE, or even side effects of NPE.
When authors submit manuscripts for this Research Topic, research articles, reviews or mini-review articles are acceptable. The themes of the articles include but are not limited to:
• Developing new NPE from various natural sources and studying their treatment efficacy towards GI malignancies.
• Investigating the specific active components of NPE for cancer prevention.
• To clarify the antitumor mechanism and safety of NPE.
• Investigating the synergistic effect of NPE and chemotherapeutic agents for GI cancers.
• Summarizing the treatment efficacy, mechanism, and safety of specific NPE for GI cancer treatment