Genetic neurodevelopmental disorders (NDDs) are individually rare but common when grouped
together. A major challenge in studying NDDs is identifying clinically useful information from a small
number of patients and genetic variants. Shared features of genetic NDDs have been identified, such as
impacting synaptic and chromatin reorganizing genes. Additionally, gene families or shared protein
complexes have been identified to have similar neurodevelopmental outcomes when variation occurs.
In this Research Topic with Frontiers in Pediatrics, we will focus on the shared features of genetic NDDs.
This includes primary research and/or review articles focused on shared mechanisms and treatments to
shared phenotypes in order to better understand how we can provide the best care to families and
individuals impacted by these disorders. Articles of interest include primary research and review articles
focused on large cohorts of related genes (gene families, protein complexes, etc), shared functional
(molecular and in vivo) phenotypes across multiple genes, or any other shared aspect of
neurodevelopmental disorders.
Genetic neurodevelopmental disorders (NDDs) are individually rare but common when grouped
together. A major challenge in studying NDDs is identifying clinically useful information from a small
number of patients and genetic variants. Shared features of genetic NDDs have been identified, such as
impacting synaptic and chromatin reorganizing genes. Additionally, gene families or shared protein
complexes have been identified to have similar neurodevelopmental outcomes when variation occurs.
In this Research Topic with Frontiers in Pediatrics, we will focus on the shared features of genetic NDDs.
This includes primary research and/or review articles focused on shared mechanisms and treatments to
shared phenotypes in order to better understand how we can provide the best care to families and
individuals impacted by these disorders. Articles of interest include primary research and review articles
focused on large cohorts of related genes (gene families, protein complexes, etc), shared functional
(molecular and in vivo) phenotypes across multiple genes, or any other shared aspect of
neurodevelopmental disorders.
