Oxidative stress (OS) is closely correlated with enhanced oxidation and decreased antioxidation under pathological conditions. Severe OS will give rise to reactive oxygen species (ROS) burst and cytotoxicity, and the excessive ROS will cause cell damage, which will affect the function of tissues and organs. Mounting evidence suggests that OS is considered to mediate in many diseases, such as cardiovascular diseases, neurodegenerative diseases, chronic kidney and pulmonary disease, inflammatory disease, diabetes, and cancer. Therefore, the effective detection of OS indicators, including ROS, their precursors and metabolites, oxidases, antioxidase, etc., will be conductive to gain insight into pathogenesis, precise diagnosis, and therapy for OS-mediated diseases.
Optical imaging possesses many advantages in monitoring bioactive species in living systems, for example real-time and in-situ, non-invasive, fast feedback, high spatial and temporal resolution and so on. With steady development of optical imaging equipment, optical imaging technologies, such as fluorescence imaging, chemiluminescence imaging, bioluminescence imaging, photoacoustic imaging, fluorescence lifetime imaging and phosphorescence lifetime imaging, have been widely used in medical diagnosis and therapy, and have made considerable progress in recent years.
There is still a lack of optical measurement methods in clinical diagnosis, although optical imaging technology has developed vigorously for more than a decade. For this purpose, the current Research Topic is intended to call for advances in oxidative stress-mediated disease diagnosis in developing optical sensors for OS indicators detection (including fluorescent sensor, chemiluminescent sensor, bioluminescent sensor, phosphorescent sensor, photoacoustic sensor) and their optical imaging applications for improvement of research on oxidative stress-mediated disease pathogenesis, diagnosis and therapy, and look forward to provide a serial of new prospective diagnostic/therapeutic agents and methods and expand application of optical imaging technology in clinical practice. The relative research achievements about this topic will also provide a timely update of this constantly growing field.
The Topic Editors encourage and welcome frontier work with outstanding significance in this Research Topic, including original Research Articles and Reviews. The scope of the Research Topic includes but is not limited to:
• Various types of optical sensors (including fluorescent, chemiluminescent, bioluminescent, phosphorescent, photoacoustic type) for oxidative stress indicators (including ROS, their precursors and metabolites, oxidase, antioxidase, etc.) detection
• Small organic molecule sensors and nanosensors for oxidative stress indicators detection
• Exploring the oxidative stress response mechanism using above-mentioned optical sensors
• New optical sensors with diagnostic and therapeutic functions for oxidative stress-mediated disease
• The optical imaging application for improving oxidative stress-mediated disease diagnosis and therapy
• The optical method of bedside detection for oxidative stress-mediated disease diagnosis
Oxidative stress (OS) is closely correlated with enhanced oxidation and decreased antioxidation under pathological conditions. Severe OS will give rise to reactive oxygen species (ROS) burst and cytotoxicity, and the excessive ROS will cause cell damage, which will affect the function of tissues and organs. Mounting evidence suggests that OS is considered to mediate in many diseases, such as cardiovascular diseases, neurodegenerative diseases, chronic kidney and pulmonary disease, inflammatory disease, diabetes, and cancer. Therefore, the effective detection of OS indicators, including ROS, their precursors and metabolites, oxidases, antioxidase, etc., will be conductive to gain insight into pathogenesis, precise diagnosis, and therapy for OS-mediated diseases.
Optical imaging possesses many advantages in monitoring bioactive species in living systems, for example real-time and in-situ, non-invasive, fast feedback, high spatial and temporal resolution and so on. With steady development of optical imaging equipment, optical imaging technologies, such as fluorescence imaging, chemiluminescence imaging, bioluminescence imaging, photoacoustic imaging, fluorescence lifetime imaging and phosphorescence lifetime imaging, have been widely used in medical diagnosis and therapy, and have made considerable progress in recent years.
There is still a lack of optical measurement methods in clinical diagnosis, although optical imaging technology has developed vigorously for more than a decade. For this purpose, the current Research Topic is intended to call for advances in oxidative stress-mediated disease diagnosis in developing optical sensors for OS indicators detection (including fluorescent sensor, chemiluminescent sensor, bioluminescent sensor, phosphorescent sensor, photoacoustic sensor) and their optical imaging applications for improvement of research on oxidative stress-mediated disease pathogenesis, diagnosis and therapy, and look forward to provide a serial of new prospective diagnostic/therapeutic agents and methods and expand application of optical imaging technology in clinical practice. The relative research achievements about this topic will also provide a timely update of this constantly growing field.
The Topic Editors encourage and welcome frontier work with outstanding significance in this Research Topic, including original Research Articles and Reviews. The scope of the Research Topic includes but is not limited to:
• Various types of optical sensors (including fluorescent, chemiluminescent, bioluminescent, phosphorescent, photoacoustic type) for oxidative stress indicators (including ROS, their precursors and metabolites, oxidase, antioxidase, etc.) detection
• Small organic molecule sensors and nanosensors for oxidative stress indicators detection
• Exploring the oxidative stress response mechanism using above-mentioned optical sensors
• New optical sensors with diagnostic and therapeutic functions for oxidative stress-mediated disease
• The optical imaging application for improving oxidative stress-mediated disease diagnosis and therapy
• The optical method of bedside detection for oxidative stress-mediated disease diagnosis
