Immunometabolism is a growing field that includes how metabolic cellular reactions process and how to control immunity and inflammation. It is a major regulation way for the adaptive and innate immune. The increasing evidence demonstrated that many metabolic pathways are highly related to immune cell signaling and differentiation. It also shows that the different subsets of immune cells would adopt specific metabolic programs for their state and environment during inflammation. Therefore, the metabolic signaling will determine the fate of the immune cells. On the other hand, the microenvironment greatly influences the metabolism of immune cells. Immune cells react to their environment and program specifically for the tissues by flexibly reprogramming the intracellular metabolic pathways. For example, T cell responses and is regulated through the interplay of serine/threonine kinases, immunological cues, and nutrient signaling networks under the promotion of cellular metabolism in adaptive immunity.
Researching the immunometabolism regulators and effectors could give hints for novel therapeutic targets to modulate metabolic programming and immune cell responses in autoimmune and autoinflammatory Disorders. Emerging research has identified that systemic inflammation and metabolism are critical for the proper regulation of the organismal level. We here discuss current research and challenges in immunometabolism, metabolism pathways, and systemic immunometabolism. We also discuss current gaps and limitations, as well as highlight opportunities, and put forward ideas for the development of therapeutic targets in autoinflammatory disorder.
The goal of this Research Topic is to provide a forum to advance research on the contribution of understanding the mechanism of immunometabolism in autoimmune and autoinflammatory disorders. Moreover, we will also explore an innovative way that could affect the metabolism and/or regulate or mimic endogenous metabolites with anti-inflammatory effects, finally to achieve a beneficial impact on the limit in autoimmune and auto-inflammation by targeting specific metabolic events and new targets.
Here, we will also discuss the concept of systemic immunometabolism and the current understanding of the communication circuits that underlie the reciprocal impact of systemic inflammation and metabolism across organs in autoimmune and autoinflammatory disorders, as well as how these mechanisms apply to the microenvironment and homeostasis.
We welcome the submission of Original Research and Review articles, including but not limited to the following:
1) Apply immunometabolism findings to the discovery of novel therapeutic strategies in autoimmunity
2) Signaling networks in immunometabolism of autoinflammatory disorders
3) Target immunometabolism as an anti-inflammatory strategy in autoinflammatory disorders
4) Discuss recent developments and speculate on the prospect of targeting immunometabolism in the effort to develop novel anti-inflammatory therapeutics
5) Systemic immunometabolism in autoinflammatory disorders
6) Novel roles of immunometabolism in macrophage activation and inflammation in autoinflammatory disorders
7) Immunometabolism in adaptive immunity of autoinflammatory disorders
Immunometabolism is a growing field that includes how metabolic cellular reactions process and how to control immunity and inflammation. It is a major regulation way for the adaptive and innate immune. The increasing evidence demonstrated that many metabolic pathways are highly related to immune cell signaling and differentiation. It also shows that the different subsets of immune cells would adopt specific metabolic programs for their state and environment during inflammation. Therefore, the metabolic signaling will determine the fate of the immune cells. On the other hand, the microenvironment greatly influences the metabolism of immune cells. Immune cells react to their environment and program specifically for the tissues by flexibly reprogramming the intracellular metabolic pathways. For example, T cell responses and is regulated through the interplay of serine/threonine kinases, immunological cues, and nutrient signaling networks under the promotion of cellular metabolism in adaptive immunity.
Researching the immunometabolism regulators and effectors could give hints for novel therapeutic targets to modulate metabolic programming and immune cell responses in autoimmune and autoinflammatory Disorders. Emerging research has identified that systemic inflammation and metabolism are critical for the proper regulation of the organismal level. We here discuss current research and challenges in immunometabolism, metabolism pathways, and systemic immunometabolism. We also discuss current gaps and limitations, as well as highlight opportunities, and put forward ideas for the development of therapeutic targets in autoinflammatory disorder.
The goal of this Research Topic is to provide a forum to advance research on the contribution of understanding the mechanism of immunometabolism in autoimmune and autoinflammatory disorders. Moreover, we will also explore an innovative way that could affect the metabolism and/or regulate or mimic endogenous metabolites with anti-inflammatory effects, finally to achieve a beneficial impact on the limit in autoimmune and auto-inflammation by targeting specific metabolic events and new targets.
Here, we will also discuss the concept of systemic immunometabolism and the current understanding of the communication circuits that underlie the reciprocal impact of systemic inflammation and metabolism across organs in autoimmune and autoinflammatory disorders, as well as how these mechanisms apply to the microenvironment and homeostasis.
We welcome the submission of Original Research and Review articles, including but not limited to the following:
1) Apply immunometabolism findings to the discovery of novel therapeutic strategies in autoimmunity
2) Signaling networks in immunometabolism of autoinflammatory disorders
3) Target immunometabolism as an anti-inflammatory strategy in autoinflammatory disorders
4) Discuss recent developments and speculate on the prospect of targeting immunometabolism in the effort to develop novel anti-inflammatory therapeutics
5) Systemic immunometabolism in autoinflammatory disorders
6) Novel roles of immunometabolism in macrophage activation and inflammation in autoinflammatory disorders
7) Immunometabolism in adaptive immunity of autoinflammatory disorders
