Intestinal inflammatory diseases include inflammatory bowel disease (IBD), celiac disease, Behcet’s disease, systemic autoimmune disease, and so on. The numerous newly published studies indicate that the interaction between gut microbiota and immune cells plays a central role in intestinal inflammation and immune regulation. For example, Roseburia intestinalis produces butyrate and flagellin to influence the balance of Treg and Th17 cells, TLR4 interacts with Akkermansia muciniphila to regulate RORγt+ regulatory T-cell responses and susceptibility to colon inflammation, microbes stimulate Toll-like receptors and B-cell receptors to synergistically induce immunoglobulin class-switch DNA recombination and others. Even in metabolic disorders such as obesity and diabetes, low-grade intestinal inflammation involves the participation of the interplay between microbiota and the immune. Importantly, gut bacteria and their metabolites can cross the gut barrier and modulate the immune cells in remote organs like the brain and liver. Thus, it’s an important topic to discuss the interaction between microbiota and the immune in intestinal inflammatory diseases.
This Research Topic is focused on recent important progress in the interactions between microbiota and immune in intestinal inflammatory diseases, gathering great insights, discoveries and methods in understanding the specific interplay mode in different inflammatory diseases.
Specifically, we welcome topics that include, but are not limited to, the following:
• How the gut microbiota influences detailed immune cell groups in intestinal inflammatory diseases;
• The innate and adaptive immune cells’ receptors and their roles in microbes signal sensing;
• The applications and roles of multi-omics data like metagenome, metabolism, immune Repertoire and Single-cell sequencing;
• The specific interplay mode of different inflammatory diseases like IBD, celiac disease, Behcet’s disease, Clostridium difficile infection, systemic autoimmune disease, metabolic disorder, gut-brain axis disorder, etc.
• The B cell’s role in the interactions between microbiota and immune in intestinal inflammatory diseases.
• Breakthroughs in new technologies and concepts for direct or indirect testing and observation of bacterial immune interactions
Intestinal inflammatory diseases include inflammatory bowel disease (IBD), celiac disease, Behcet’s disease, systemic autoimmune disease, and so on. The numerous newly published studies indicate that the interaction between gut microbiota and immune cells plays a central role in intestinal inflammation and immune regulation. For example, Roseburia intestinalis produces butyrate and flagellin to influence the balance of Treg and Th17 cells, TLR4 interacts with Akkermansia muciniphila to regulate RORγt+ regulatory T-cell responses and susceptibility to colon inflammation, microbes stimulate Toll-like receptors and B-cell receptors to synergistically induce immunoglobulin class-switch DNA recombination and others. Even in metabolic disorders such as obesity and diabetes, low-grade intestinal inflammation involves the participation of the interplay between microbiota and the immune. Importantly, gut bacteria and their metabolites can cross the gut barrier and modulate the immune cells in remote organs like the brain and liver. Thus, it’s an important topic to discuss the interaction between microbiota and the immune in intestinal inflammatory diseases.
This Research Topic is focused on recent important progress in the interactions between microbiota and immune in intestinal inflammatory diseases, gathering great insights, discoveries and methods in understanding the specific interplay mode in different inflammatory diseases.
Specifically, we welcome topics that include, but are not limited to, the following:
• How the gut microbiota influences detailed immune cell groups in intestinal inflammatory diseases;
• The innate and adaptive immune cells’ receptors and their roles in microbes signal sensing;
• The applications and roles of multi-omics data like metagenome, metabolism, immune Repertoire and Single-cell sequencing;
• The specific interplay mode of different inflammatory diseases like IBD, celiac disease, Behcet’s disease, Clostridium difficile infection, systemic autoimmune disease, metabolic disorder, gut-brain axis disorder, etc.
• The B cell’s role in the interactions between microbiota and immune in intestinal inflammatory diseases.
• Breakthroughs in new technologies and concepts for direct or indirect testing and observation of bacterial immune interactions