Natural products and their derivatives and mimics are characterized by structural diversity, diverse biologic activities, low toxicity and side effects, and availability of a wide range of sources, most of which are derived from herbs that have been utilized long in traditional medicine. It is demonstrated that several well-known natural products have potential immunomodulatory effects in inflammatory diseases. However, there is still a considerable lag in developing natural products as novel therapeutic strategies. The immunoregulation mechanisms of natural products and their derivatives and mimics are complex and involve multiple signal transduction pathways for the prevention and treatment of inflammatory diseases.
This Research Topic calls for a joint collaborative effort to address the immunopharmacology in inflammatory diseases, including the highest-quality reviews, timely summaries of original research articles, and perspectives covering a broad scope that investigate the emerging topics in natural products and derivatives as immunomodulating agents against inflammatory diseases, and options of the latest advances in the immunopharmacological effects and mechanisms of natural products and derivatives and mimics at both basic and clinical research area.
The subtopics to be covered include, but are not limited to:
1. Discussing the latest progress in the relationship between natural products and inflammation diseases.
2. Identifying new formulations or recognizing new therapeutic molecules based on natural products for increasing anti-inflammation effectiveness and reducing toxicity.
3. Exploring the roles of natural products in the immune system and exploring the potential treatment of immunologic and inflammatory diseases using natural products and derivatives and mimics in the basic research area.
4. Exploring the roles of natural products in the immune system and explore the potential treatment of immunologic and inflammatory diseases using natural products and derivatives and mimics in the clinical research area.
5. Discovering novel mechanistic insights and targeted therapies of natural products-based drugs for inflammation diseases.
All the manuscripts submitted to this project will be peer-reviewed, us a ‘VALID’ approach
(https://www.frontiersin.org/about/peer-review) and need to fully comply with the
Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version
here). Importantly, please ascertain that the ethnopharmacological context is clearly described (pillar 3d) and that the material investigated is characterized in detail (pillars 2 a / b and Front. Pharmacol. 13:953205. https://doi.org/10.3389/fphar.2022.953205).
