Osteoporosis and osteoarthritis are the most common bone degenerative diseases affecting aging populations with high morbidity worldwide. Osteoporosis and osteoarthritis are characterized by deregulated skeletal homeostasis and deformed bone and cartilage architecture. Patients' symptoms include significant pain, loss of function, and bone and joint disability. Osteoporosis increases fracture incidence in patients and end-stage osteoarthritis impairs joint function for which arthroplasty is the only treatment option currently. Therefore, there is an urgent and necessary need for research into advanced therapeutic strategies to prevent and treat osteoarthritis and osteoporosis.
A fine balance between anabolism and catabolism could maintain the homeostasis of bone and cartilaginous metabolism. However, under pathologic conditions, this balance is disrupted and switched to a metabolically imbalanced state. This results in diseases such as osteoporosis and osteoarthritis. To better understand the pathological physiology of these diseases, the underlying molecular mechanisms have been explored, and many target proteins for pharmacological investigations have been identified in the past few decades. Moreover, various therapeutic strategies have been attempted for the treatment of osteoporosis and osteoarthritis. However, currently, no drug candidates have been completely successful due to adverse side effects and low therapeutic efficacy. This Research Topic aims to further investigate the underlying mechanisms of osteoarthritis and osteoporosis and discover new drugs or target proteins to treat bone and cartilaginous diseases and their ultimate regeneration.
This Research Topic invites researchers to contribute studies including original research and review articles on advances in therapeutic strategies for degenerative diseases of bone and joints. We welcome submissions focusing on, but not limited to, the following themes:
1. Basic and clinical studies on the pharmacological therapy of bone and joint diseases, including but not limited to osteoporosis, osteoarthritis, and osteonecrosis.
2. Exploring the underlying mechanisms of drugs in regulating bone metabolism and cartilaginous metabolism.
3. Finding a potential protein that might be a target candidate for the treatment of bone and joint diseases.
4. Detecting and evaluating the adverse side effects of current drugs on modulating bone metabolism and cartilaginous metabolism.
Osteoporosis and osteoarthritis are the most common bone degenerative diseases affecting aging populations with high morbidity worldwide. Osteoporosis and osteoarthritis are characterized by deregulated skeletal homeostasis and deformed bone and cartilage architecture. Patients' symptoms include significant pain, loss of function, and bone and joint disability. Osteoporosis increases fracture incidence in patients and end-stage osteoarthritis impairs joint function for which arthroplasty is the only treatment option currently. Therefore, there is an urgent and necessary need for research into advanced therapeutic strategies to prevent and treat osteoarthritis and osteoporosis.
A fine balance between anabolism and catabolism could maintain the homeostasis of bone and cartilaginous metabolism. However, under pathologic conditions, this balance is disrupted and switched to a metabolically imbalanced state. This results in diseases such as osteoporosis and osteoarthritis. To better understand the pathological physiology of these diseases, the underlying molecular mechanisms have been explored, and many target proteins for pharmacological investigations have been identified in the past few decades. Moreover, various therapeutic strategies have been attempted for the treatment of osteoporosis and osteoarthritis. However, currently, no drug candidates have been completely successful due to adverse side effects and low therapeutic efficacy. This Research Topic aims to further investigate the underlying mechanisms of osteoarthritis and osteoporosis and discover new drugs or target proteins to treat bone and cartilaginous diseases and their ultimate regeneration.
This Research Topic invites researchers to contribute studies including original research and review articles on advances in therapeutic strategies for degenerative diseases of bone and joints. We welcome submissions focusing on, but not limited to, the following themes:
1. Basic and clinical studies on the pharmacological therapy of bone and joint diseases, including but not limited to osteoporosis, osteoarthritis, and osteonecrosis.
2. Exploring the underlying mechanisms of drugs in regulating bone metabolism and cartilaginous metabolism.
3. Finding a potential protein that might be a target candidate for the treatment of bone and joint diseases.
4. Detecting and evaluating the adverse side effects of current drugs on modulating bone metabolism and cartilaginous metabolism.
