About this Research Topic
Population-based studies have addressed the potential interaction between mood and cognitive impairment in old age. However, there are few studies to explore the potential neural mechanism of the relationship between depression and cognitive impairment in old age.
In all of this process the contribution of multiple biological events cannot be neglected, particularly the underlying influence of chronic diseases and concomitant polymedication as well as the geriatric conditions, like frailty, frequently present in this elderly population, which also compromise the cognitive function and mood determining depression and conducing to worse outcomes with more morbidity and mortality.
We welcome the submission of manuscripts that address the new findings concerning mood and cognition in old age, including normal aging and age-related diseases, e.g., elderly depression, mild cognitive impairment, and Alzheimer’s disease. The studies are expected to be based on clinical research and neuroscience techniques, including but not limited to neurochemical assay, gene sequencing, functional magnetic resonance imaging, electroencephalography, diffusion tensor imaging, and contributions on the biomarkers of mood and cognition as well as the inherent concepts of comorbidity and frailty in aging, are highly encouraged. All these studies would enrich our understanding of neural and biological mechanisms underlying improving psychological well-being and cognitive health.
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