Research Topic

Interaction between Diabetes and Alzheimer’s Disease: Toward Development of Next-generation Therapeutic Options

  • Submission closed.

About this Research Topic

More than 35 million patients suffer from dementia, while 380 million battle against diabetes in this aging society. Emerging evidence suggests that diabetes increases the risk of dementia; however, the underlying mechanisms remain to be fully elucidated. Clinical studies have suggested that diabetes is ...

More than 35 million patients suffer from dementia, while 380 million battle against diabetes in this aging society. Emerging evidence suggests that diabetes increases the risk of dementia; however, the underlying mechanisms remain to be fully elucidated. Clinical studies have suggested that diabetes is associated with brain atrophy, including the frontal and temporal lobes, and symptomatically decreased executive function, information processing, memory, and other cognitive functions. Diabetes thus appears to affect cognitive function not only by simple Alzheimer’s disease (AD)-dependent mechanisms, but also independent mechanisms. Diabetes compromises cerebrovascular function, increases the risk of subcortical infarction, and also affects glucose metabolism, insulin signaling, and mitochondrial function in neurons. Moreover, increasing evidence suggests that lipid and glucose metabolism is implicated in modulating the pathogenesis of AD. Further discussion on the relation between diabetes and AD is strongly encouraged from both basic and clinical aspects.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top