The major obstetrical complications including preeclampsia, intrauterine growth restriction (IUGR), preterm labor (PTL), preterm prelabor rupture of membranes (PROM), fetal demise, and recurrent abortions are all syndromes, also defined as “great obstetrical syndromes”. Key features of these syndromes are: multiple etiologies; long preclinical stage; frequent fetal involvement; clinical manifestations which are often adaptive in nature; and predisposition to a particular syndrome is influenced by gene–environment interaction and/or complex gene–gene interactions involving maternal and/or fetal genotypes. These mechanisms of disease were identified and reported in all the obstetrical complications listed above.
All the above mentioned pregnancy complications are reported at higher rates in women conceiving through assisted reproductive techniques compared to spontaneous conceptions.
We are still far from the full understanding of the pathophysiology of pregnancy complications. Therefore, the aim of the present Research Topic is to collect updates on the pathophysiology, the prevention, the management of the Great Obstetrical Syndromes, taking into consideration the contribution of assisted reproductive techniques to their development and the severity of their outcomes.
The major obstetrical complications including preeclampsia, intrauterine growth restriction (IUGR), preterm labor (PTL), preterm prelabor rupture of membranes (PROM), fetal demise, and recurrent abortions are all syndromes, also defined as “great obstetrical syndromes”. Key features of these syndromes are: multiple etiologies; long preclinical stage; frequent fetal involvement; clinical manifestations which are often adaptive in nature; and predisposition to a particular syndrome is influenced by gene–environment interaction and/or complex gene–gene interactions involving maternal and/or fetal genotypes. These mechanisms of disease were identified and reported in all the obstetrical complications listed above.
All the above mentioned pregnancy complications are reported at higher rates in women conceiving through assisted reproductive techniques compared to spontaneous conceptions.
We are still far from the full understanding of the pathophysiology of pregnancy complications. Therefore, the aim of the present Research Topic is to collect updates on the pathophysiology, the prevention, the management of the Great Obstetrical Syndromes, taking into consideration the contribution of assisted reproductive techniques to their development and the severity of their outcomes.
