Research Topic

The Importance of Protein Dynamics for function and its relevance to Antigen Processing and Presentation

  • Submission closed.

About this Research Topic

The molecular mechanisms that underpin antigen processing and presentation are central to understanding the control of immune responsiveness. Consequently they are important for understanding and manipulating the immune system in normal and disease states. Over the last decades, charactersiation of the atomic ...

The molecular mechanisms that underpin antigen processing and presentation are central to understanding the control of immune responsiveness. Consequently they are important for understanding and manipulating the immune system in normal and disease states. Over the last decades, charactersiation of the atomic structures and interactions between key molecules in the pathway has greatly advanced our understanding of immunology. More recently insight into the contribution of atomic scale dynamics of these proteins has highlight the significance of protein plasticity in controlling immune system function.

Proteins are pliable and exist in nature as dynamic entities whose structures fluctuate between different conformations at rates varying over a wide range of timescales. The development of increasingly sophisticated methods for the study of protein dynamics has enabled the structural biology community to demonstrate the functional significance of these motions leading to an extension of the structure–function paradigm to include dynamics.

Several articles in this Research Topic will focus on the developments of concepts, simulations and experimental approaches in the study of protein dynamics with regards to protein folding, enzyme function and molecular recognition with a particular focus and examples of how these affect our understanding of immunology.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top