About this Research Topic
Cannabidiol (CBD) is the main non-psychotropic component of the glandular hairs of Cannabis sativa. It displays a plethora of actions for human health, since its anticonvulsive, sedative, hypnotic, antipsychotic, anti-cancer, anti-inflammatory and neuroprotective effects. CBD produces its biological effects without exerting significant intrinsic activity upon cannabinoid receptors. For this reason, CBD lacks the unwanted psychotropic effects characteristic of marijuana derivatives, so representing one of the bioactive constituents of Cannabis sativa with the highest potential for therapeutic use. CBD is a compound well tolerated in humans, with a very low toxicity, and devoid of psychoactive and cognitive effects. Preliminary studies highlight these remarkably important properties and encourage further experiments to be performed in more complex systems in order to clarify the mechanism(s) responsible for its molecular and cellular actions. At the same time, since most of the investigations suggesting CBD as a novel medicine with substantial neuroprotective potential have been carried out in the most part in animal or then cellular models, then more clinical trials able to validate its beneficial properties are warranted. The results generated by these trials might allow that the current promising expectative can progress from the present preclinical evidence to a practical therapeutic application.
To increase the scientific exchange in the field, we encourage investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to expand the knowledge of this field of CBD research. In particular we are interested in articles describing the effects of CBD in many neuro-inflammatory conditions in both central nervous system (CNS) and in peripheral nervous system (PNS). Original articles, but also review articles are thus welcome on the following topics:
- Molecular pharmacology of CBD
- Pharmacognosy of CBD
- CBD in the brain and in the gut pathology
- CBD in psychiatric disorders
- CBD in cancer
- CBD in the clinic
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.