About this Research Topic
The goal of this research topic is to enhance our understanding of changes in gene expression, epigenetic and transcriptional regulation in neurodegenerative diseases and ageing, and to generate testable hypotheses on possible therapeutic targets and early diagnostics markers. Microarray and next generation sequencing studies are extremely useful as they aid in depicting molecular and genetic determinants between healthy and diseased, or between young and old individuals. Particularly, differential gene expression studies often identify genes relevant to disease pathophysiology and diagnosis and help in understanding the molecular mechanisms leading to disease development.
We welcome submission of Original Research, Reviews, Methods, and Perspective articles. Studies with both animal models and humans are welcomed. We are seeking articles in the following areas of research (but other topics will be considered):
• Gene expression analyses
• Transcriptomic data analysis
• Chromatin Immunoprecipitation Sequencing (ChIP-Seq)
• Next-generation sequencing
• Epigenetic studies
• Differential expression studies
• Regulation of biological processes in neurodegenerative diseases or ageing
• Critical evaluations of the hypothesis that neurodegeneration is an accelerated form of ageing
Keywords: Neurodegenerative diseases, Ageing, Parkinson’s diseases, Dementia, Ataxia, Transcription, Epigenetics, Gene regulation, Gene expression, Transcriptomics, Systems biology, Computational biology, Next generation sequencing, Alzheimer’s disease
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.