The lack of early diagnostics markers or cures for neurodegenerative diseases continues to be a major challenge for society, especially as their incidence is expected to rise as the world's population ages. Molecular and genetic studies have shown that alterations in protein aggregation, synaptic transmission, and mitochondrial pathways are a common denominator in many of these diseases. However, these changes can also be found in healthy elderly individuals, which may indicate that neurodegenerative diseases cause accelerated ageing.
The goal of this research topic is to enhance our understanding of changes in gene expression, epigenetic and transcriptional regulation in neurodegenerative diseases and ageing, and to generate testable hypotheses on possible therapeutic targets and early diagnostics markers. Microarray and next generation sequencing studies are extremely useful as they aid in depicting molecular and genetic determinants between healthy and diseased, or between young and old individuals. Particularly, differential gene expression studies often identify genes relevant to disease pathophysiology and diagnosis and help in understanding the molecular mechanisms leading to disease development.
We welcome submission of Original Research, Reviews, Methods, and Perspective articles. Studies with both animal models and humans are welcomed. We are seeking articles in the following areas of research (but other topics will be considered):
• Gene expression analyses
• Transcriptomic data analysis
• Chromatin Immunoprecipitation Sequencing (ChIP-Seq)
• Next-generation sequencing
• Epigenetic studies
• Differential expression studies
• Regulation of biological processes in neurodegenerative diseases or ageing
• Critical evaluations of the hypothesis that neurodegeneration is an accelerated form of ageing
The lack of early diagnostics markers or cures for neurodegenerative diseases continues to be a major challenge for society, especially as their incidence is expected to rise as the world's population ages. Molecular and genetic studies have shown that alterations in protein aggregation, synaptic transmission, and mitochondrial pathways are a common denominator in many of these diseases. However, these changes can also be found in healthy elderly individuals, which may indicate that neurodegenerative diseases cause accelerated ageing.
The goal of this research topic is to enhance our understanding of changes in gene expression, epigenetic and transcriptional regulation in neurodegenerative diseases and ageing, and to generate testable hypotheses on possible therapeutic targets and early diagnostics markers. Microarray and next generation sequencing studies are extremely useful as they aid in depicting molecular and genetic determinants between healthy and diseased, or between young and old individuals. Particularly, differential gene expression studies often identify genes relevant to disease pathophysiology and diagnosis and help in understanding the molecular mechanisms leading to disease development.
We welcome submission of Original Research, Reviews, Methods, and Perspective articles. Studies with both animal models and humans are welcomed. We are seeking articles in the following areas of research (but other topics will be considered):
• Gene expression analyses
• Transcriptomic data analysis
• Chromatin Immunoprecipitation Sequencing (ChIP-Seq)
• Next-generation sequencing
• Epigenetic studies
• Differential expression studies
• Regulation of biological processes in neurodegenerative diseases or ageing
• Critical evaluations of the hypothesis that neurodegeneration is an accelerated form of ageing