T cells play a central role in the immune system and impact many non-immune organ functions. Dysfunctions in T cells during aging are associated with age-related diseases, such as metabolic diseases, neurodegenerative diseases, and cardiovascular diseases. The two most displays of T cells with age are “immune deficiency” and “inflamm-aging” associated with decreased ratio of naïve/memory T cells and accumulation of senescent T cells. Causality between T cell dysfunction with aging and age-related features was documented by a recent study in which inflamm-aging induced by TFAM-deficient T cells driver multiple premature alterations, such as metabolic, musculoskeletal, cardiovascular and cognitive defects. This places T cell dysfunction induced by aging at a central role in body-wide age-related changes. Alzheimer’s disease is a well-known age-related disease, and a recent study shows that clonally expanded CD8 cells increased in peripheral and brain of AD patients which have distinct functional characteristics which indicate T cells involvement in AD. However, the relationship between T cells and age-related diseases and how they influence each other is unclear. This topic aims to deepen and expand our understanding of the role of T cells in age-related diseases.
The goal of this Research Topic is to provide a forum to advance research on mechanisms underlying T cells’ alteration with aging and roles of T cells in specific age-related diseases or aging processes, as well as to explore innovative immune pharmacological interventions via rejuvenating aged T cells in the attempt to achieve a beneficial impact on aging-related diseases and the aging process.
1) Mechanisms of T cell aging
2) T cells profile at different age-related diseases
3) Alterations of T cells in age-related diseases
4) Roles and mechanisms of impact of T cell aging on age-related diseases or aging process
5) Therapeutic strategies for correct dysfunctional T cells
T cells play a central role in the immune system and impact many non-immune organ functions. Dysfunctions in T cells during aging are associated with age-related diseases, such as metabolic diseases, neurodegenerative diseases, and cardiovascular diseases. The two most displays of T cells with age are “immune deficiency” and “inflamm-aging” associated with decreased ratio of naïve/memory T cells and accumulation of senescent T cells. Causality between T cell dysfunction with aging and age-related features was documented by a recent study in which inflamm-aging induced by TFAM-deficient T cells driver multiple premature alterations, such as metabolic, musculoskeletal, cardiovascular and cognitive defects. This places T cell dysfunction induced by aging at a central role in body-wide age-related changes. Alzheimer’s disease is a well-known age-related disease, and a recent study shows that clonally expanded CD8 cells increased in peripheral and brain of AD patients which have distinct functional characteristics which indicate T cells involvement in AD. However, the relationship between T cells and age-related diseases and how they influence each other is unclear. This topic aims to deepen and expand our understanding of the role of T cells in age-related diseases.
The goal of this Research Topic is to provide a forum to advance research on mechanisms underlying T cells’ alteration with aging and roles of T cells in specific age-related diseases or aging processes, as well as to explore innovative immune pharmacological interventions via rejuvenating aged T cells in the attempt to achieve a beneficial impact on aging-related diseases and the aging process.
1) Mechanisms of T cell aging
2) T cells profile at different age-related diseases
3) Alterations of T cells in age-related diseases
4) Roles and mechanisms of impact of T cell aging on age-related diseases or aging process
5) Therapeutic strategies for correct dysfunctional T cells
