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About this Research Topic

Manuscript Submission Deadline 14 January 2023
Manuscript Extension Submission Deadline 13 February 2023

Cytokines are soluble proteins secreted by a wide variety of cells in the body, playing crucial roles in many physiological responses and are involved in the pathophysiology of cardiovascular diseases (CVDs). Recently, there is great progress in discoveries that some novel cytokines, including secreted ...

Cytokines are soluble proteins secreted by a wide variety of cells in the body, playing crucial roles in many physiological responses and are involved in the pathophysiology of cardiovascular diseases (CVDs). Recently, there is great progress in discoveries that some novel cytokines, including secreted frizzled-related proteins (SFRPs), adiponectin, and C1q/TNF-Related Proteins (CTRPs), can perform a protective effect in cardiometabolic diseases, heart failure and coronary heart disease. However, the mechanisms underlying the molecular and pathophysiological actions of these cytokines in CVDs are still vague. Novel mechanisms of cell death including pyroptosis, autophagy, ferroptosis, cuproptosis, and PANoptosis have been considered novel therapeutic targets for CVDs. Some cytokines have been shown to regulate the cell death pathway in the incidence and development of CVDs. Further investigations are needed to understand the link between these novel cytokines and novel cell death models and pathways in CVDs.

In this Research Topic, we would like to create a forum for discussing the role of novel cytokines (including pro-inflammatory and anti-inflammatory cytokines, such as secreted frizzled-related proteins, adiponectin, fibroblast growth factors) in the development and progression of cardiometabolic diseases, including but not limited to coronary artery disease, heart failure, diabetes, and stroke. We are also interested in the physiological mechanisms that link cytokines and CVDs, especially in the field of novel cell death models (e.g., pyroptosis, ferroptosis, PANoptosis, et al.). We also expect clinical or experimental studies evaluating the effects of potential novel therapeutics by modifying the secretion of cytokines and novel cell death models in cardiometabolic diseases.

Topics of interest include but are not limited to:
- The relationship between cytokines and cardiovascular diseases, including cardiometabolic disease, heart failure, coronary heart disease and atrial fibrillation
- The effects of novel cell death pathways such as autophagy, pyroptosis, ferroptosis, and cuproptosis in cardiovascular disease
- The molecular mechanisms of novel cytokines (e.g., myokines, adipokines and inflammatory factors) in the cell death pathways of cardiovascular diseases
- Cytokines as biomarkers or therapeutic targets in cardiovascular diseases

Keywords: cardiovascular disease, cytokines, adipokines, pyroptosis, ferroptosis, PANoptosis, signal pathways


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