Cellular aging and stresses can lead to accidental cell death and regulated cell death (RCD). RCD involves molecularly defined apoptotic and non-apoptotic cellular signaling cascades. Non-apoptotic forms of RCD pathways, such as pyroptosis, necroptosis, ferroptosis, autophagy, efferocytosis, parthanatos, entosis, lysosomal cell death, and NETosis, have been identified and are increasingly being implicated in various normal and pathological conditions in humans. Although cell death seems to be a deleterious cellular response, proper RCD regulations are critical for maintaining normal somatic cell turnover, tissue repair, tumor clearance and pathogen defense. On the other hand, abnormal stimulation or suppression of RCD by pathological agents, such as toxic agents, metabolic defects, chromic inflammation, tumors and pathogens, may lead to an exacerbated phenotype of RCD-associated diseases. Accordingly, most of the RCD regulating pathways are potential drug targets. To get a better understanding of RCD pathways in the initiation and reversal of inflammation and tissue repair will help develop feasible therapeutic strategy to manage RCD-associated diseases.
This Research Topic aims to provide an overview of current advances in characterizing RCD in healthy and pathological conditions, with a special focus on how different RCD regulating pathways cross-talk with one other. It will also focus on how different RCD regulating signals determine the fate of dying cells and surrounding tissues, how RCD defects are related to disease progression, leading to suppressed tissue repair, and how therapeutic interventions may help to overcome such defects.
In this Research Topic, we welcome submissions of Original Research, Review, Mini Review, Opinion and Methods articles that address, but are not limited to, the following subtopics:
• Characterization of RCD in healthy and pathological conditions.
• Cross-regulation of RCD pathways.
• RCD regulating signals on the determination of dying cell fate and spillover effect on surrounding tissues.
• Therapeutic interventions and reprograming of RCD regulating signals on rescue of disease progression and enhancement of tissue repair.
• New techniques on the characterization of RCD pathways.
Cellular aging and stresses can lead to accidental cell death and regulated cell death (RCD). RCD involves molecularly defined apoptotic and non-apoptotic cellular signaling cascades. Non-apoptotic forms of RCD pathways, such as pyroptosis, necroptosis, ferroptosis, autophagy, efferocytosis, parthanatos, entosis, lysosomal cell death, and NETosis, have been identified and are increasingly being implicated in various normal and pathological conditions in humans. Although cell death seems to be a deleterious cellular response, proper RCD regulations are critical for maintaining normal somatic cell turnover, tissue repair, tumor clearance and pathogen defense. On the other hand, abnormal stimulation or suppression of RCD by pathological agents, such as toxic agents, metabolic defects, chromic inflammation, tumors and pathogens, may lead to an exacerbated phenotype of RCD-associated diseases. Accordingly, most of the RCD regulating pathways are potential drug targets. To get a better understanding of RCD pathways in the initiation and reversal of inflammation and tissue repair will help develop feasible therapeutic strategy to manage RCD-associated diseases.
This Research Topic aims to provide an overview of current advances in characterizing RCD in healthy and pathological conditions, with a special focus on how different RCD regulating pathways cross-talk with one other. It will also focus on how different RCD regulating signals determine the fate of dying cells and surrounding tissues, how RCD defects are related to disease progression, leading to suppressed tissue repair, and how therapeutic interventions may help to overcome such defects.
In this Research Topic, we welcome submissions of Original Research, Review, Mini Review, Opinion and Methods articles that address, but are not limited to, the following subtopics:
• Characterization of RCD in healthy and pathological conditions.
• Cross-regulation of RCD pathways.
• RCD regulating signals on the determination of dying cell fate and spillover effect on surrounding tissues.
• Therapeutic interventions and reprograming of RCD regulating signals on rescue of disease progression and enhancement of tissue repair.
• New techniques on the characterization of RCD pathways.
