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About this Research Topic

Abstract Submission Deadline 08 January 2023
Manuscript Submission Deadline 12 February 2023

Understanding the molecular and behavioral underpinnings of brain function is critical to identifying novel therapeutic avenues to maintain and promote brain health, tackling conditions and pathologies ranging from mental and neurological disorders to neurodegenerative diseases and regeneration after injury. To that end, the modeling, validation, and implementation of in vitro and in vivo models of brain function and disease with translational potential is vital.

The aim of this Research Topic is to gather contributions from a wide array of scientists currently developing and working with diverse (i.e. cellular, animal or in silico) models for brain function and disease, with the overarching goal to provide translational approaches. In particular, this Research Topic is geared toward the identification of disease-modifying mechanisms and agents, a key limitation of current treatments.

We welcome all forms of submissions: Original Research Articles, Review Articles, Method Articles, Clinical Trials, Case Reports, Mini Review Articles, Code, Book Reviews, General Commentaries, Perspectives, Hypotheses & Theories, focused but not limited to the following subtopics:



- Computational approaches to understand brain function and disease

- Novel models of neurodegenerative diseases

- Translational behavioral neuroscience in neurological and neurodegenerative diseases.

- Identification of novel druggable pathways of neurological and neurodegenerative diseases

- Novel approaches to promote neuroregeneration


Michael Edel is the co-founder and CEO of Regenacellx.sl. The other Topic Editors declare no competing interests with regard to the Research Topic subject.

Keywords: Neurodegeneration, cognition, Regeneration, animal models, brain health, disease-modifying mechanisms, Translational behavioral neuroscience Social neuroscience, neuronal vulnerability and resilience


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Understanding the molecular and behavioral underpinnings of brain function is critical to identifying novel therapeutic avenues to maintain and promote brain health, tackling conditions and pathologies ranging from mental and neurological disorders to neurodegenerative diseases and regeneration after injury. To that end, the modeling, validation, and implementation of in vitro and in vivo models of brain function and disease with translational potential is vital.

The aim of this Research Topic is to gather contributions from a wide array of scientists currently developing and working with diverse (i.e. cellular, animal or in silico) models for brain function and disease, with the overarching goal to provide translational approaches. In particular, this Research Topic is geared toward the identification of disease-modifying mechanisms and agents, a key limitation of current treatments.

We welcome all forms of submissions: Original Research Articles, Review Articles, Method Articles, Clinical Trials, Case Reports, Mini Review Articles, Code, Book Reviews, General Commentaries, Perspectives, Hypotheses & Theories, focused but not limited to the following subtopics:



- Computational approaches to understand brain function and disease

- Novel models of neurodegenerative diseases

- Translational behavioral neuroscience in neurological and neurodegenerative diseases.

- Identification of novel druggable pathways of neurological and neurodegenerative diseases

- Novel approaches to promote neuroregeneration


Michael Edel is the co-founder and CEO of Regenacellx.sl. The other Topic Editors declare no competing interests with regard to the Research Topic subject.

Keywords: Neurodegeneration, cognition, Regeneration, animal models, brain health, disease-modifying mechanisms, Translational behavioral neuroscience Social neuroscience, neuronal vulnerability and resilience


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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