SUMOylation is a posttranslational modification in which the small ubiquitin-like modifier (SUMO) groups are covalently attached to specific lysine residues on substrate proteins. Many cellular processes, including transcription, RNA processing, ribosome maturation, cell growth, and DNA damage repair, rely on SUMOylation. Diseases may be caused by SUMOylation dysregulation.
Recently, it has been reported that SUMOylation plays important roles in both innate and adaptive immune responses, as well as the interaction between pathogens and the host immune system. Further research into the crosstalk between SUMOylation system and immune system will help us better understand the immune system and identify potential therapeutic targets in infectious or immune diseases.
This Research Topic aims to cover the latest progress in research on the crosstalk between SUMOylation system and immune system and the roles of SUMOylation system in the battle between pathogens and the host immune system. We welcome Original Research articles focusing on, but not limited to, the following subtopics:
1. SUMOylation in adaptive immune receptor signaling and activation;
2. SUMOylation in innate immune receptor signaling and activation;
3. Regulation of SUMOylation system by immune signaling;
4. SUMOylation in the battle between pathogens and the host.
Topic Editor Dr. Guoping Deng is employed by GentiBio, United States. All other Topic Editors declare no competing interests with regard to the Research Topic subject.
SUMOylation is a posttranslational modification in which the small ubiquitin-like modifier (SUMO) groups are covalently attached to specific lysine residues on substrate proteins. Many cellular processes, including transcription, RNA processing, ribosome maturation, cell growth, and DNA damage repair, rely on SUMOylation. Diseases may be caused by SUMOylation dysregulation.
Recently, it has been reported that SUMOylation plays important roles in both innate and adaptive immune responses, as well as the interaction between pathogens and the host immune system. Further research into the crosstalk between SUMOylation system and immune system will help us better understand the immune system and identify potential therapeutic targets in infectious or immune diseases.
This Research Topic aims to cover the latest progress in research on the crosstalk between SUMOylation system and immune system and the roles of SUMOylation system in the battle between pathogens and the host immune system. We welcome Original Research articles focusing on, but not limited to, the following subtopics:
1. SUMOylation in adaptive immune receptor signaling and activation;
2. SUMOylation in innate immune receptor signaling and activation;
3. Regulation of SUMOylation system by immune signaling;
4. SUMOylation in the battle between pathogens and the host.
Topic Editor Dr. Guoping Deng is employed by GentiBio, United States. All other Topic Editors declare no competing interests with regard to the Research Topic subject.
