Migraine is a highly prevalent and complex disorder causing low quality of health and emotional status. The Global Burden of Disease Study confirms that migraine is one of the leading causes of disability and disease burden globally. Additionally, migraine is an important and possibly independent risk factor for cerebrovascular diseases (including migrainous infarction, ischemic stroke, and white matter abnormalities, etc), and often leads to comorbid anxiety and depression which adversely affects the treatment outcomes of migraine. However, mechanisms underlying migraine itself and comorbidities are not well-understood. The complexity of cause and symptom in migraine is associated with changes in different levels of nervous system, from molecular interaction, synaptic connection, inflammatory cellular responses, and neural circuits. The development of new acute and preventive treatments shall base on a better understanding of neurophysiological mechanisms underlying symptoms, a further exploration on diagnosis methods, and a more practical transition from preclinical models to clinical applications.
We launch this Research Topic, aiming to bring together a collection of papers focusing on neurophysiological mechanisms of the development and chronification of migraine and novel technical methods for identifying migraine and its comorbidities. These insights will encourage the discussion on how to achieve a better outcome in clinical managements of migraine. Original articles, reviews, and focus articles related to basic, translational, and clinical research are all welcome.
We look forward to the articles on the following topics, including, but not limited to:
• Neuroinflammatory processes and related signaling pathways in migraine and/or its comorbidities.
• Synaptic and circuit plasticity underlying migraine headache and associated symptoms, including photophobia, phonophobia, nausea and vestibular symptoms.
• Crosstalk mechanisms between neurons and glia in neuroplasticity.
• Application of the latest neuroimaging and electroencephalogram (EEG) techniques in the differential diagnosis of migraine and its comorbidities.
• New drugs or innovative use of traditional medicines, and psychotherapies for migraine treatment.
• Perspective and review articles focusing on the interactions between migraine headache and associated symptoms and comorbidities.
Migraine is a highly prevalent and complex disorder causing low quality of health and emotional status. The Global Burden of Disease Study confirms that migraine is one of the leading causes of disability and disease burden globally. Additionally, migraine is an important and possibly independent risk factor for cerebrovascular diseases (including migrainous infarction, ischemic stroke, and white matter abnormalities, etc), and often leads to comorbid anxiety and depression which adversely affects the treatment outcomes of migraine. However, mechanisms underlying migraine itself and comorbidities are not well-understood. The complexity of cause and symptom in migraine is associated with changes in different levels of nervous system, from molecular interaction, synaptic connection, inflammatory cellular responses, and neural circuits. The development of new acute and preventive treatments shall base on a better understanding of neurophysiological mechanisms underlying symptoms, a further exploration on diagnosis methods, and a more practical transition from preclinical models to clinical applications.
We launch this Research Topic, aiming to bring together a collection of papers focusing on neurophysiological mechanisms of the development and chronification of migraine and novel technical methods for identifying migraine and its comorbidities. These insights will encourage the discussion on how to achieve a better outcome in clinical managements of migraine. Original articles, reviews, and focus articles related to basic, translational, and clinical research are all welcome.
We look forward to the articles on the following topics, including, but not limited to:
• Neuroinflammatory processes and related signaling pathways in migraine and/or its comorbidities.
• Synaptic and circuit plasticity underlying migraine headache and associated symptoms, including photophobia, phonophobia, nausea and vestibular symptoms.
• Crosstalk mechanisms between neurons and glia in neuroplasticity.
• Application of the latest neuroimaging and electroencephalogram (EEG) techniques in the differential diagnosis of migraine and its comorbidities.
• New drugs or innovative use of traditional medicines, and psychotherapies for migraine treatment.
• Perspective and review articles focusing on the interactions between migraine headache and associated symptoms and comorbidities.
