Neutrophils are the most important innate immune cells in the body defense against invading pathogenic microorganisms and play an essential role in the early defense against tissue injury by their adhesion, exudation, and activation to apoptosis. In the process of infection or tissue injury, neutrophils are the first to reach the sites of inflammation. Neutrophils phagocytose pathogenic microorganisms by recognizing specific signals such as chemokines or bacterial products released near the lesion. They release bioactive substances such as proteolytic enzymes, arachidonic acid metabolites, reactive oxygen species, and cytokines, etc., to enhance the body's ability to eliminate pathogenic microorganisms. In addition, endothelial migration is a key physiological process in angiogenesis, growth, development, and a variety of disease processes. By attaching and passing through the endothelial lining at the base of the blood vessel, mass migration of neutrophils to organs such as the lungs and kidneys may trigger pathological inflammation, which is thought to be a contributing factor in diseases involving endothelial migration.
This Research Topic is focused on the responses of neutrophils and endothelial cells in infectious diseases and their roles in clinical diagnosis. The dysregulated host response to infection in inflammation is due to excessive neutrophils infiltrating into the vital organs and endothelial dysfunction, which leads to severe organ failure. The interactions between neutrophils and endothelial cells may contribute to the early process of organ damage during inflammatory responses. However, the molecular mechanism of this interaction has not been completely elucidated and therefore more novel studies are needed to understand the underlying mechanisms of neutrophil-endothelial cell interactions, which will provide new strategies for the diagnosis and prognosis of infectious diseases.
We welcome submissions on the following subtopics:
1. Exploring the interaction between neutrophils and endothelial cells in infectious diseases
2. Exploring the molecular mechanism between neutrophils and endothelial cells in infectious diseases
3. Exploring the role of neutrophil-endothelial cell interaction in the diagnosis and prognosis of diseases
Neutrophils are the most important innate immune cells in the body defense against invading pathogenic microorganisms and play an essential role in the early defense against tissue injury by their adhesion, exudation, and activation to apoptosis. In the process of infection or tissue injury, neutrophils are the first to reach the sites of inflammation. Neutrophils phagocytose pathogenic microorganisms by recognizing specific signals such as chemokines or bacterial products released near the lesion. They release bioactive substances such as proteolytic enzymes, arachidonic acid metabolites, reactive oxygen species, and cytokines, etc., to enhance the body's ability to eliminate pathogenic microorganisms. In addition, endothelial migration is a key physiological process in angiogenesis, growth, development, and a variety of disease processes. By attaching and passing through the endothelial lining at the base of the blood vessel, mass migration of neutrophils to organs such as the lungs and kidneys may trigger pathological inflammation, which is thought to be a contributing factor in diseases involving endothelial migration.
This Research Topic is focused on the responses of neutrophils and endothelial cells in infectious diseases and their roles in clinical diagnosis. The dysregulated host response to infection in inflammation is due to excessive neutrophils infiltrating into the vital organs and endothelial dysfunction, which leads to severe organ failure. The interactions between neutrophils and endothelial cells may contribute to the early process of organ damage during inflammatory responses. However, the molecular mechanism of this interaction has not been completely elucidated and therefore more novel studies are needed to understand the underlying mechanisms of neutrophil-endothelial cell interactions, which will provide new strategies for the diagnosis and prognosis of infectious diseases.
We welcome submissions on the following subtopics:
1. Exploring the interaction between neutrophils and endothelial cells in infectious diseases
2. Exploring the molecular mechanism between neutrophils and endothelial cells in infectious diseases
3. Exploring the role of neutrophil-endothelial cell interaction in the diagnosis and prognosis of diseases