About this Research Topic
Treatment of metastatic melanoma has developed into two major therapeutic advances. Targeted therapies using BRAF and MEK inhibitors towards the BRAF mutation-driven, constitutively-activated MAPK pathway and immunotherapy using immune checkpoint inhibitors. The most common immune checkpoint inhibitors used in the treatment of melanomas include anti-CTLA4 and anti-PD-1 antibodies. Immune checkpoint inhibitors induce cancer-cell-killing CD8-positive T cells by targeting the immune system. The use of immunotherapy has revolutionized the treatment of Melanomas however concerns arise with immune-related adverse events. This Research Topic explores immunotherapy's use for treating melanomas, including the success and drawbacks of the treatment.
For this Research Topic, we welcome submissions of Original Research and Reviews highlighting the advances in immunotherapy in melanomas.
Please note: manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
Keywords: Immunotherapy, Melanoma
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