About this Research Topic
In the last years, functional alterations associated with aging have been studied using the mathematical notion of graph theory that offers an integrative approach since it examines different properties of the brain network: 1) Organization level 2) amount of local information processing, 3) information flow 4) cortical community structure and 5) identification of functional / anatomical hubs. So, graph theory offers an attractive way to model brain networks organization and to quantify their pathological deviations.
Previous studies have already employed this mathematical notion and demonstrated that age-related neurodegeneration is often accompanied by loss of optimal network organization either due to diminished local information processing or due to progressive isolation of distant brain regions. They have also found that changes in network properties may be present even in the preclinical phase, which could be taken as a biological marker of disease.
Despite the great envisaged impact and the importance of such studies, there is scarce research aiming to quantify whether still great lack of literature aiming to quantify whether the decrease of network performance with age follows a linear trajectory. In this sense, an outstanding question is whether this trajectory could be changed via non-invasive intervention such as cognitive and physical training, which are thought to induce brain plasticity changes. The present research topic aims at hosting studies that propose new brain network models, or validate existing ones for healthy and pathological aging and studies that test or propose contemporary techniques derived from graph theory or other methods, to assess the efficacy of non-pharmacological interventions in aging or age-related neurodegenerative disorders Therefore, we welcome studies that answer fundamental neuroscientific questions like (but not limited to) the following:
1. Is there a linear decrease of brain network performance across the life span?
2. What are the age-related changes in the brain (hubs) and how these changes may be related to pathological neurodegeneration?
3. How can we detect/quantify compensatory mechanisms through brain network properties?
4. How do we establish evaluation models for quantifying the impact of interventions in terms of brain network properties?
5. What is the optimal identification of network states and how do they evolve during aging?
Keywords: Brain Networks, Neurodegeneration, Life-span, Non-pharmacological intervention, Training evaluation, Functional organization
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.