Trace elements are essential for the biological, chemical and molecular activities of cell. These agents play a key role in biochemical reactions by acting as cofactors for enzymes. The use of trace elements including copper, zinc, selenium, and magnesium is an important procedure in the management of type 2 diabetes mellitus. It has been showed that these agents have exerted hypoglycemic and insulin-mimetic effects.
However, it is not known whether an imbalance in these elements is the consequence of diabetes or a factor contributing to its development. Previous research suggests a relationship between diabetes mellitus and trace elements; an alteration of zinc, copper, manganese, and chromium levels can produce a failure on the antioxidant capacity. On the other hand, trace elements may cause both apoptosis and necrosis of cells in tissue. The relationship between trace elements and cell death is contradictory. Ferroptosis is an iron-dependent form of regulated necrosis. It is implicated in various human diseases, including ischemic organ damage and cancer. Here, we report the crucial role of autophagy and the other cell deaths.
It has been demonstrated that both the excess and the lack of trace elements could play role in the appearance and evolution of diabetes mellitus. This topic investigates the relationship between type 2 diabetes mellitus and trace element levels in saliva as well as other body fluid and tissues. This is also in the hope of identifying useful markers and that new therapy approaches may be discovered.
The main purpose of this Research Topic is to integrate the scientific knowledge we have about major and minor elements, minerals, mechanisms, ferroptosis, autophagy, apoptosis and antioxidant systems and their involvement in the pathophysiology of type 2 diabetes mellitus. We welcome all investigators in the field to submit their Original Research articles (basic and clinical studies), Reviews, and Perspectives.
Trace elements are essential for the biological, chemical and molecular activities of cell. These agents play a key role in biochemical reactions by acting as cofactors for enzymes. The use of trace elements including copper, zinc, selenium, and magnesium is an important procedure in the management of type 2 diabetes mellitus. It has been showed that these agents have exerted hypoglycemic and insulin-mimetic effects.
However, it is not known whether an imbalance in these elements is the consequence of diabetes or a factor contributing to its development. Previous research suggests a relationship between diabetes mellitus and trace elements; an alteration of zinc, copper, manganese, and chromium levels can produce a failure on the antioxidant capacity. On the other hand, trace elements may cause both apoptosis and necrosis of cells in tissue. The relationship between trace elements and cell death is contradictory. Ferroptosis is an iron-dependent form of regulated necrosis. It is implicated in various human diseases, including ischemic organ damage and cancer. Here, we report the crucial role of autophagy and the other cell deaths.
It has been demonstrated that both the excess and the lack of trace elements could play role in the appearance and evolution of diabetes mellitus. This topic investigates the relationship between type 2 diabetes mellitus and trace element levels in saliva as well as other body fluid and tissues. This is also in the hope of identifying useful markers and that new therapy approaches may be discovered.
The main purpose of this Research Topic is to integrate the scientific knowledge we have about major and minor elements, minerals, mechanisms, ferroptosis, autophagy, apoptosis and antioxidant systems and their involvement in the pathophysiology of type 2 diabetes mellitus. We welcome all investigators in the field to submit their Original Research articles (basic and clinical studies), Reviews, and Perspectives.
