Malignant lymphomas are a heterogeneous group of malignancies that develop both in nodal and extranodal sites and arise from the clonal proliferation of B-cell, T-cell and natural killer (NK) cell subsets of lymphocytes at different stages of maturation. The different tissues involved and the highly variable clinicopathological characteristics are linked to the association between the lymphoid neoplastic cells and the tumor microenvironment (TME). The TME, a complex network that comprises cellular and noncellular components forming a physical barrier around tumor cells, plays an important role in lymphomagenesis. Interactions between lymphoma cells and elements of TME are vital for the survival and proliferation of the neoplastic cells, in addition to somatic mutations and inflammation.
TME of lymphomas shows a range of extent and composition partly reflecting tumour cell content and acquired genetic aberrations harbored by the lymphoma cells. Specifically, the lymphoma microenvironment is increasingly being recognized as a dynamic and interactive supporting network including immune cells, stromal cells, cytokines, blood vessels, and extracellular matrix components, whose composition is guided by the neoplastic cells and which, in turn, influence tumor initiation, progression, resistance to cell death, evasion of growth suppressors and drug resistance.
Although the roles of the TME have not been fully elucidated, accumulating evidence implies that TME is closely relevant to the origination, invasion, and dissemination of lymphomas. A full understanding of TME biology and the interaction between lymphoma cells and the TME, as well as the host's immune system and the TME, is necessary to provide distinctive insights into therapeutic potential. The aim of this Research Topic will be to collect original articles and reviews to better understand the key components of the lymphoma environment, as well as their interplay.
Please note: manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
Malignant lymphomas are a heterogeneous group of malignancies that develop both in nodal and extranodal sites and arise from the clonal proliferation of B-cell, T-cell and natural killer (NK) cell subsets of lymphocytes at different stages of maturation. The different tissues involved and the highly variable clinicopathological characteristics are linked to the association between the lymphoid neoplastic cells and the tumor microenvironment (TME). The TME, a complex network that comprises cellular and noncellular components forming a physical barrier around tumor cells, plays an important role in lymphomagenesis. Interactions between lymphoma cells and elements of TME are vital for the survival and proliferation of the neoplastic cells, in addition to somatic mutations and inflammation.
TME of lymphomas shows a range of extent and composition partly reflecting tumour cell content and acquired genetic aberrations harbored by the lymphoma cells. Specifically, the lymphoma microenvironment is increasingly being recognized as a dynamic and interactive supporting network including immune cells, stromal cells, cytokines, blood vessels, and extracellular matrix components, whose composition is guided by the neoplastic cells and which, in turn, influence tumor initiation, progression, resistance to cell death, evasion of growth suppressors and drug resistance.
Although the roles of the TME have not been fully elucidated, accumulating evidence implies that TME is closely relevant to the origination, invasion, and dissemination of lymphomas. A full understanding of TME biology and the interaction between lymphoma cells and the TME, as well as the host's immune system and the TME, is necessary to provide distinctive insights into therapeutic potential. The aim of this Research Topic will be to collect original articles and reviews to better understand the key components of the lymphoma environment, as well as their interplay.
Please note: manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
