Research on microbes plays an essential role in the improvement of biotechnological and biomedical areas. It has turned into a subject of expanding significance as new organisms and their related biomolecules are being characterized. Microbial biomolecules confer the ability of microbes to cope with a range of adverse conditions. However, these bimolecules have several advantages over the plant origin, which makes them a suitable target in drug discovery and development. The reasons could be that microbial sources can be genetically engineered to enhance the production of desired natural production by large-scale fermentation. The interaction between microbes and their biotic and abiotic environment is fundamental to numerous processes taking place in the biosphere. The natural environments and hosts of these microorganisms are extremely diverse being reflected by the fact that microbes are widespread and occur in nearly every biological community on Earth. This metabolic versatility makes microbes interesting objects for a range of economically important biotechnological applications. Most of the biotechniques are established but unefficient genetic engineering strategies are forms still a bottelneck for selected microbe producing industrical scale biomolecules. Therefore, untapped microbial biodiversity and related metablomics, gives a noteworthy wellspring of biologicals for the advancement of meds, immunizations, enhanced plants and for other natural applications. Industrialized countries, who have the innovation and assets to patent and create commercial bioproducts, are having the advantages of microbial biodiversity.

Replenished interest in biochemistry, genomics, proteomics, metabolomics, metabolic engineering and system biology studies of microbes is likewise important in improvement of microbial cell factories for industial innovations. To completely explore the biotechnological applications, abobe diementiones have to be resolved. So, within the scope of the proposed Research Topic, we aim to publish articles on microbial secondary metabolites, microbial biosynthetic potential including biosynthetic gene expression, metagenomics and authors are encouraged to submit articles dealing with microorganism from unique habitats like marine sources, endophytes, thermal springs, deserts, etc. We encourage submissions of original research articles, short communications, reviews, mini-reviews, methods articles, perspectives and opinions that make a considerable and efficient contribution to the scientific community.

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.