About this Research Topic
Since general anesthetics have a direct effect on the brain, studying the impact of anesthesia on brain function is a key topic in the field of anesthesiology. Both the developing brain and the degenerating brain are extremely susceptible to the effects of general anesthetics. Therefore, it is crucial to study the effects of general anesthetics on these two populations.
Anesthesiology has transformed from providing anesthesia during surgery to perioperative medicine, with brain health as the primary focus. Brain health during and after surgery should be a collaborative effort between different medical disciplines, with screenings and diagnosis of any potential brain complications or diseases before surgery. During surgery, brain function should be monitored closely to avoid any damage, and after surgery patients should be closely monitored for any post-operative complications. The perioperative period carries a risk for several cognitive deficits, including perioperative neurocognitive dysfunction, perioperative stroke, and cerebral ischemia/reperfusion injury. Additionally, general anesthetics may have neurodevelopmental toxicity.
The bottleneck of current research on perioperative brain health is that the role of different subtypes of nerve cells in brain diseases caused by general anesthesia and surgery is not clear. Single-cell sequencing technologies can directly measure multiple molecular signatures in thousands to millions of individual cells. Elucidating the role of different neuronal cell subtypes in perioperative brain homeostasis is a very important fundamental question.
This Research Topic aims to investigate the influence of multiple factors on fetal or infant neurodevelopmental toxicity and cognitive dysfunction, including but not limited to the heterogeneity of different nerve cell types, the effects of anesthesia and surgery, the levels of blood glucose and lipid, the brain energy metabolism, nanotechnology, cutting-edge technology, drug screening, cell metabolic study, etc. We invite authors to contribute original research articles, reviews, bioinformatics, machine learning, and risk analysis to open problems in these areas.
It is essential to note that when 'cognition' is an outcome, studies do not solely use basic screening measures (e.g., MMSE, MOCA, etc.). As typically done in animal models, measures of cognition should be specific rather than solely using broad or simplistic screening assessment.
Keywords: anesthesia/surgery, postoperative cognitive dysfunction, postoperative delirium, neurotoxicity, single-cell sequencing, nanotechnology, biomarker
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.