Angiogenesis plays a key role in the progression of malignant tumors. Studies have shown that the occurrence and development of colorectal cancer, gastric cancer, liver cancer, pancreatic cancer and other gastrointestinal malignancies are always accompanied by an upregulated level of angiogenesis. The realization of this process requires the regulation of a variety of key angiogenic proteins and signalling pathways. Stimulating angiogenesis can promote the proliferation, invasion and metastasis of malignant tumors. There has also been considerable progress in tumor treatment strategies based on tumor vascular correlation. Further studies revealed that high levels of angiogenesis were dependent on the expression of vascular growth factors and the regulation of various key proteins as well as signalling pathways related to angiogenesis. There is a need to recognize that angiogenic key proteins and associated signalling pathways are both critical in anti-tumour therapeutic strategies.
In recent years, the development of anti-angiogenesis targeted drugs has made rapid progress, providing more options for tumor therapy. However, adaptive resistance and compensatory resistance limit the use of targeted antiangiogenic agents and there is no standardized and sophisticated treatment plan to make up for this shortcoming. Thus this Research Topic aims to further study the regulatory network and target of tumor angiogenesis to provide new insights for anti-tumor targeted therapy. And we call for articles on novel antitumor agents as well, especially from natural products.
The welcomed scope of this Research Topic includes but is not limited to:
— Novel studies on the mechanism of tumor angiogenesis and its treatments
— Novel targeted drugs against tumor angiogenesis and their mechanisms
— Research progress and coping strategies of antitumor angiogenesis therapy
— Role of tumor microenvironment in tumor angiogenesis
— Other novel therapies of antitumor angiogenesis and their mechanisms
— Relationship between tumor anti-angiogenesis and immunotherapy
— Effect of protein modification on tumor angiogenesis
— Research on natural products targeting tumor angiogenesis
Angiogenesis plays a key role in the progression of malignant tumors. Studies have shown that the occurrence and development of colorectal cancer, gastric cancer, liver cancer, pancreatic cancer and other gastrointestinal malignancies are always accompanied by an upregulated level of angiogenesis. The realization of this process requires the regulation of a variety of key angiogenic proteins and signalling pathways. Stimulating angiogenesis can promote the proliferation, invasion and metastasis of malignant tumors. There has also been considerable progress in tumor treatment strategies based on tumor vascular correlation. Further studies revealed that high levels of angiogenesis were dependent on the expression of vascular growth factors and the regulation of various key proteins as well as signalling pathways related to angiogenesis. There is a need to recognize that angiogenic key proteins and associated signalling pathways are both critical in anti-tumour therapeutic strategies.
In recent years, the development of anti-angiogenesis targeted drugs has made rapid progress, providing more options for tumor therapy. However, adaptive resistance and compensatory resistance limit the use of targeted antiangiogenic agents and there is no standardized and sophisticated treatment plan to make up for this shortcoming. Thus this Research Topic aims to further study the regulatory network and target of tumor angiogenesis to provide new insights for anti-tumor targeted therapy. And we call for articles on novel antitumor agents as well, especially from natural products.
The welcomed scope of this Research Topic includes but is not limited to:
— Novel studies on the mechanism of tumor angiogenesis and its treatments
— Novel targeted drugs against tumor angiogenesis and their mechanisms
— Research progress and coping strategies of antitumor angiogenesis therapy
— Role of tumor microenvironment in tumor angiogenesis
— Other novel therapies of antitumor angiogenesis and their mechanisms
— Relationship between tumor anti-angiogenesis and immunotherapy
— Effect of protein modification on tumor angiogenesis
— Research on natural products targeting tumor angiogenesis