RNA epigenetic modifications have revealed that RNA is not simply an intermediary between DNA and protein or an effector molecule, but that it also plays significant roles in post-transcriptional gene regulation. To date, over 100 types of chemical modification have been identified in cellular RNAs. Among these, m6A is the most abundant and conserved internal RNA modification. More recently, the identification of methyltransferase, demethylase, and binding proteins that install, remove or recognize m6A has revealed unappreciated roles of m6A in almost every aspect of RNA metabolism as well as in various physiological and pathological processes. However, there are still a lot of unknowns about the role of epigenetic modification of RNA in genetic development and immune regulation.
This research topic aims to collect the contributions of scientists in various fields (e.g., the genetic development of animals and plants, the immune response of human diseases), mainly focusing on the interaction between epigenetic modification of RNA, genetic development, and immune regulation. Provide theoretical support for the cultivation of new animal and plant varieties and the treatment of disease.
We welcome all forms of submissions: Original Research Articles, Review Articles, Method Articles, Clinical Trials, Case Reports, Mini Review Articles, Code, Book Reviews, General Commentaries, Perspectives, Hypotheses & Theories, focused but not limited to the following subtopics:
- RNA modification in genetic development.
- RNA modification in immune regulation (mainly in cancer).
- Targeting RNA modification for immunotherapy and new variety breeding.
RNA epigenetic modifications have revealed that RNA is not simply an intermediary between DNA and protein or an effector molecule, but that it also plays significant roles in post-transcriptional gene regulation. To date, over 100 types of chemical modification have been identified in cellular RNAs. Among these, m6A is the most abundant and conserved internal RNA modification. More recently, the identification of methyltransferase, demethylase, and binding proteins that install, remove or recognize m6A has revealed unappreciated roles of m6A in almost every aspect of RNA metabolism as well as in various physiological and pathological processes. However, there are still a lot of unknowns about the role of epigenetic modification of RNA in genetic development and immune regulation.
This research topic aims to collect the contributions of scientists in various fields (e.g., the genetic development of animals and plants, the immune response of human diseases), mainly focusing on the interaction between epigenetic modification of RNA, genetic development, and immune regulation. Provide theoretical support for the cultivation of new animal and plant varieties and the treatment of disease.
We welcome all forms of submissions: Original Research Articles, Review Articles, Method Articles, Clinical Trials, Case Reports, Mini Review Articles, Code, Book Reviews, General Commentaries, Perspectives, Hypotheses & Theories, focused but not limited to the following subtopics:
- RNA modification in genetic development.
- RNA modification in immune regulation (mainly in cancer).
- Targeting RNA modification for immunotherapy and new variety breeding.