About this Research Topic
To date, studies exploring the role of cognitive, motor, and brain reserve on the clinical evolution of age-related, and neurodegenerative phenotypes are still few. Also, fine-grain measures of reserve factors are scarce, and the underlying biological mechanisms (cellular, molecular, and neural mechanisms) are for the most part unknown. Research may help in understanding how accumulated reserve may be the outcome of specific bio-behavioral arrangements and phenotypes.
This topic calls for studies investigating the role of reserve factors acting in the life-span by preventing age-related decline, unsuccessful aging (i.e., the frailty phenotype), and slowing disease progression or enhancing rehabilitation-related changes in clinical conditions (i.e., Parkinson’s disease, Huntington’s disease, Mild Cognitive Impairment, Alzheimer’s disease, Frontotemporal dementia, and other forms of dementia, Multiple Sclerosis, etc...).
Brief Research Report, Case Report, Clinical Trial, Conceptual Analysis, Hypothesis and Theory, Methods, Mini Review, Original Research, and Systematic Review will be welcomed. Especially we are looking for:
- Cross-sectional or longitudinal studies on detecting different phenotypes characterizing high and low reserve in typical and atypical conditions, and/or the prognostic role of different levels of reserve.
- Studies proposing and/or validating new methods/measures of cognitive, motor, and brain reserve (e.g., specific neural morphometrical indexes, and pattern of functional connectivity).
- Neuroimaging studies exploring the biological substrates involved in reserve scaffolding.
Keywords: cognitive reserve, motor reserve, brain reserve, ageing, neurodegeneration, dementia
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