About this Research Topic
The goal of this research topic is to highlight the importance of early detection of DPN. How early detection could provide the best outcome for treatment of painful DPN as well as development of DPN. For clinical trials of DPN to be successful reliable endpoints at the earliest stage of the disease in needed. About 30% of subjects with DPN suffer from painful conditions that negatively impacts their daily living and quality of life. Current medications are far from successful in treating this condition and new approaches are needed to provide relief for these patients. An article in this research topic will examine the potential benefit of proper dose management and use of combinations of agents to achieve pain relief. We will re-visit pre-clinical studies of diabetic rodents to determine what combination therapies will have the potential for best outcome for DPN management. Finally, we will consider which end-points may enable us to successfully navigate the graveyard of clinical trials in DPN.
Professor Dinesh Selvarajah will provide an article detailing the advancements of brain imaging for the detection of painful DPN and potential of this important methodology as a tool for determining treatment outcome success objectively. The title of his review article; 'New Neurobiology of Painful Diabetic Neuropathy: Insights from Neuroimaging Studies'.
Professor Solomon Tesfaye will provide an article describing the current state of treatment of painful DPN and the potential benefit of combination therapy on this debilitating and demoralizing condition of DPN. The title of his review article; ‘Combination treatment for painful diabetic neuropathy’.
Professor Rayaz Malik will address why we currently have no FDA approved disease modifying therapies for DPN in relation to inadequate end-points in clinical trials. He will then focus on how corneal confocal microscopy could be used to detect early DPN and nerve regeneration in clinical trials of disease modifying treatments. The title of his review article is; ‘Clinical trials in diabetic neuropathy: A time to challenge the dogma’.
Dr. Mark Yorek will provide information from pre-clinical studies of the rationale and success of combination therapy in rodent models of DPN and which ones may provide the best chance of success in human subjects. The title of his article; ‘Combination Therapy is it the Future for Successfully Treating Peripheral Diabetic Neuropathy?’
Other contributions focusing on early detection and successful treatment of DPN are encouraged.
Keywords: Diabetes, Peripheral Neuropathy, Etiology, Intervention, Early Detection
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