About this Research Topic
This research topic focuses on programmed cell death in bone related cells, with an aim of delineating how PCD contributes to the initiation and progression of bone disease. Addressing these issues will advance our understanding of PCD pathophysiology in bone disease and provide new strategies for treatment.
Contributions addressing the roles and mechanisms of PCD in bone disease are welcome for this research topic, including original articles presenting new findings as well as reviews summarizing the advances of the field. Specific themes include, but are not limited to:
• The impact of PCD on degenerative joint and bone diseases;
• Novel PCD-related mechanisms in bone diseases, e.g. ferroptosis, copper death;
• Novel detection methods or biomarkers of PCD in bone-related cells;
• New therapeutic strategies target PCD development in bone and joint diseases;
• Crosstalk between different programmed cell death processes in bone diseases;
• The different PCD-related pathways and processes in bone and joint, such as the progression of autophagy or senescence in osteoarthritis.
Keywords: Cell death; Bone metabolism; Bone homeostasis; Bone development; Therapeutic strategies
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.