About this Research Topic
The combination of agent-based modelling and single-cell analysis has been dubbed microbial individual-based ecology or individual-based microbiology. It has been increasingly used in environmental and food microbiology, among others, for the understanding of the systems behavior and the study of emergent patterns at the population level. Individual-based microbiology has particularly succeeded in describing microbial systems as varied as biofilms, phytoplankton communities or soils. One of its strengths is that it also allows for the incorporation of both lower and higher levels of organization into the individual-based framework. Integrating lower levels of organization enables a more mechanistic approach for simulating single cell behavior based on systems microbiology models for intracellular structure and dynamics. By integrating higher levels of organization, feedbacks between multiple levels in multiple species communities systems can also be tackled, grouping them into functional groups where necessary.
This Research Topic will solicit contributions advancing the connection between individual microbes with intracellular and/or population levels including (but not limited to) heterogeneity, diversity and structure in microbial populations, interactions of microbes within the population and with their environment, and intracellular biochemical mechanisms and networks, among others. Both modelling and experimental approaches are solicited in each area, either together or separately.
Keywords: Microbial individual-based ecology, Multi-scale modelling, Biofilms, Spatial structure, Bet hedging, Division of labor
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