About this Research Topic
Nonetheless, the pathogenesis of aortopathy associated with BAV is not yet well understood. A genetic predisposition can be associated in different degrees and forms to abnormal regional blood flow patterns in the ascending aorta created by cusp fusion and abnormal BAV morphology, leading to localized areas of aortopathy.
The coexistence of these mechanisms can contribute to the heterogeneous patterns of aortic dilation often seen in BAV patients. Aggressive surgical management strategies with respect to the timing and extent of aortic resection are often applied to BAV patients to prevent the occurrence of fatal TAAA. A more in-depth knowledge of the mechanisms at the basis of aortopathy associated with BAV could be helpful in a redefinition of the guidelines for surgical intervention in BAV patients.
On this basis, we would like to propose to the Editor of Frontiers in Physiology, section Vascular Physiology, a Research Topic including the multiple pathogenetic mechanisms of aortopathy, including the hemodynamics and biomechanics aspects, the development of animal models of disease, the identification of key molecular pathways involved in alterations of the phenotype of endothelial and smooth muscle cells and in mechanosensing, and the identification of potential early biomarkers of aortopathy, including microRNAs or other circulating molecules. To this aim, we selected potential contributors to this Research Topic on the basis of their well-known expertise and background in the field.
Keywords: bicuspid aortic valve, aortopathy, hemodynamics, biomarkers, remodeling
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.