Frontiers in Cell Death is a multidisciplinary open-access journal at the forefront of disseminating and communicating scientific knowledge and impactful discoveries in Cell Death research to a broad community of researchers, academics, clinicians, and other relevant stakeholders.

Able to occur in both an accidental or programmed manner, the concept of Cell Death and Programmed Cell Death has evolved dramatically. Many diverse pathways expanding on the well-studied Apoptosis with multiple forms of necrotic cell death have now been identified, as have forms of Programmed Cell Death with specific finely regulated molecular machineries, including necroptosis, pyroptosis, and ferroptosis. However, the nature of true accidental cell death is still largely elusive.

This journal serves as a unique and reliable repository of applicable research to better our understanding of Cell Death (accidental and programmed), and address the fundamental questions remaining in the field (i.e. true accidental cell death). Cell Death research also has wider applications to new medicines targeting cell death and development of novel therapeutics.

This Research Topic is dedicated to collecting forward-looking articles composed by the Chief Editors of the journal. These contributions will identify and reflect upon what could be dubbed the “grand challenges” in Cell Death research in the following specialties:

· Apoptosis: This section examines the physiological, pathological and pharmacological conditions relating to apoptosis and therapeutic interventions.
· Model Systems in Cell Death: This section examines the use of in vivo model systems to better understand the diversity of mechanisms that mediate death.
· Cellular Stress and Survival: This section examines the impacts cellular physiology has on cellular processes and survival responses with an emphasis on crosslinks, intersections, and death pathways.
· Non-Apoptotic Regulated Cell Death: This section focuses on all forms of non-apoptotic cell death, such as necrosis and autophagy, and their significance in development, physiology and disease pathology and intervention.

Are you interested in contributing a manuscript to this Research Topic?

Grand Challenges in Cell Death Research