Research Topic

Cancer Models

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The topics to be covered in this Research Topic concern nearly all of the currently used cancer models. This includes animal models like the mouse, the zebrafish, the domestic pig and possibly others. All these model organisms have specific advantages, like short generation time and ease of genetic ...

The topics to be covered in this Research Topic concern nearly all of the currently used cancer models. This includes animal models like the mouse, the zebrafish, the domestic pig and possibly others. All these model organisms have specific advantages, like short generation time and ease of genetic manipulation which allows to perform studies impossible with human material.

In the mouse model, patient derived tumor cells can be xenografted and studied in vivo. In another approach, the immune system of the mouse is humanized in order to investigate the immune defense against cancer. The reaction of the immune system to tumors and their eventual escape from the immune system will be reviewed.

The large field of cellular models includes cells directly isolated from patients, cell lines derived from tumors, and three-dimensional cellular models of cancer. The prototypic eukaryotic cells of yeast also offer insights into cancer biology. One example is introducing chromosomal translocations at defined points at will and studying effects on genomic stability, drug resistance and metabolism of the cells, which models the situation in cancer cells. Another one is the regulation and physiological function (in signal transduction) of NADPH oxidases in yeast and cancer cells. Tumor-derived cell lines are studied to gain insight into the metabolism and signaling discriminating cancer cells from normal somatic cells. A global picture of the metabolic network of cancer cells is studied by analyzing metabolomics of cancer cells compared to primary somatic cell lines, by reviewing the current state of the Warbug hypothesis of cancer cells, and by in silico modeling of the cancer cell’s metabolome. Another related topic to be presented is mathematical models in cancer research.

Cellular senescence is presently discussed intensively as a possible anti-tumor strategy of somatic cells. How is this process related to the inevitable process of organismic aging? What is the correct explanation of the fact that the incidence of most cancers increases exponentially with age?

Drug resistance of tumor cells is studied in cancer cell lines.

The concept of tumor stem cells will be reviewed.


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