The emergence and rapid spread of SARS-Cov-2 across the world, infecting millions of the population in process, posed a global health emergency. Following the Coronavirus disease 2019 (COVID-19) outbreak, an increasing number of patients who survived worldwide continue to struggle with local inflammation, fibrosis, and fatigue for a certain time during recovery. These patients are battling with “Post-Acute COVID-19 or SARS-CoV-2 (PASC),” manifested by prolonged symptoms such as dyspnea, cough, and brain fog for several months after recovery from COVID-19. There are no known predictors or causes for the onset of PASC symptoms which are diverse among patients. Investigating the presence of “memory” in immune cells of patients who have already suffered from allergic symptoms may shed light on the relation of PASC symptoms among allergic patients. Also, establishing the interaction between the blood-brain barrier and inflammatory immune response could possibly explain the involvement of the central nervous system in PASC symptoms.
With this Research Topic, we would like to bridge the gap between inflammatory and neurological response among allergic patients suffering from PASC. We also wish to explore whether having a high predisposition to allergy affects the presence and duration of PASC symptoms.
This Research Topic welcomes all article types accepted by Frontiers in Allergy. Suitable themes include, but are not limited to:
a. Cytokines and neuroinflammatory mediators present in PASC allergic patients
b. Bridging the gap between neuroinflammation and other PASC symptoms
c. Cell signaling during neuroinflammation in allergic patients
d. The efficacy of allergy treatments against PASC symptoms
e. Inflammatory memory exhibited by immune cells already exposed to allergic triggers
f. Cellular mechanisms involved in the interaction of the blood-brain barrier and inflammatory response
g. The role of the cytokine network in PASC and allergic patients
h. Establishment of novel immune cell markers or mediators predicative of PASC symptoms
i. Investigating chronic fatigue syndrome in allergic patients
j. The role of trained immunity in PASC exhibited by allergic patients
Keywords:
PASC, Allergy, Neuroimmune mediators, inflammation, chronic fatigue syndrome, Immune memory
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
The emergence and rapid spread of SARS-Cov-2 across the world, infecting millions of the population in process, posed a global health emergency. Following the Coronavirus disease 2019 (COVID-19) outbreak, an increasing number of patients who survived worldwide continue to struggle with local inflammation, fibrosis, and fatigue for a certain time during recovery. These patients are battling with “Post-Acute COVID-19 or SARS-CoV-2 (PASC),” manifested by prolonged symptoms such as dyspnea, cough, and brain fog for several months after recovery from COVID-19. There are no known predictors or causes for the onset of PASC symptoms which are diverse among patients. Investigating the presence of “memory” in immune cells of patients who have already suffered from allergic symptoms may shed light on the relation of PASC symptoms among allergic patients. Also, establishing the interaction between the blood-brain barrier and inflammatory immune response could possibly explain the involvement of the central nervous system in PASC symptoms.
With this Research Topic, we would like to bridge the gap between inflammatory and neurological response among allergic patients suffering from PASC. We also wish to explore whether having a high predisposition to allergy affects the presence and duration of PASC symptoms.
This Research Topic welcomes all article types accepted by Frontiers in Allergy. Suitable themes include, but are not limited to:
a. Cytokines and neuroinflammatory mediators present in PASC allergic patients
b. Bridging the gap between neuroinflammation and other PASC symptoms
c. Cell signaling during neuroinflammation in allergic patients
d. The efficacy of allergy treatments against PASC symptoms
e. Inflammatory memory exhibited by immune cells already exposed to allergic triggers
f. Cellular mechanisms involved in the interaction of the blood-brain barrier and inflammatory response
g. The role of the cytokine network in PASC and allergic patients
h. Establishment of novel immune cell markers or mediators predicative of PASC symptoms
i. Investigating chronic fatigue syndrome in allergic patients
j. The role of trained immunity in PASC exhibited by allergic patients
Keywords:
PASC, Allergy, Neuroimmune mediators, inflammation, chronic fatigue syndrome, Immune memory
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.