About this Research Topic
The kidneys play a key role in Mg homeostasis. In acute kidney injury (AKI) and chronic kidney disease (CKD), serum Mg level rises and hypermagnesemia may occur. On the other hand, lower serum Mg level (hypomagnesemia) or lower dietary Mg intake is associated with increased risks of CKD progression, kidney stone formation, and cardiovascular diseases. Because of the role of the kidney in Mg homeostasis, key Mg2+ channels in both paracellular and transcellular pathways were first identified by studies of inherited disorders of renal Mg reabsorption. It is also evident that the kidney is among the first “victims” if Mg homeostasis is disrupted. Thus, the relationship between Mg metabolism and kidney health is an important area of research and represents one of the frontiers in renal physiology.
Despite the recent progress in Mg homeostasis and regulation, many gaps remain in our current knowledge of the mechanisms of renal Mg handling and the roles of Mg in kidney diseases. Compared to other electrolytes such as sodium, potassium, and calcium, Mg lags in terms of the awareness of its role in diseases, the availability of research tools and animal models, and overall research efforts. This research topic on “magnesium homeostasis and kidney health” will serve as a platform for timely publication of new findings, improvements of research tools and models, research summaries, hypotheses, and ideas in the area broadly related to Mg and kidney.
All topics related to Mg and kidney health and disease are welcome. The types of manuscripts in this research topic include but are not limited to original research, reviews (systemic, regular, and mini), method, and hypothesis and theory. Note that case reports and clinical studies are not permitted. Topics in the following areas are especially encouraged:
- Roles of Mg in preventing nephrocalcinosis and nephrolithiasis
- Disorders involving disrupted renal Mg handling
- Tools and methods in Mg research
- Intracellular Mg homeostasis
- Roles of magnesium in CKD and AKI
- Regulation of magnesium channels and transporters
- Physiological regulation of Mg reabsorption
Topic Editor Ji-Bin Peng is an inventor of the United States Patents 6534642 and 7078178. These patents are related to calcium channel TRPV6.
Keywords: magnesium, kidney, ckd, aki, channels, transporters, Mg reabsorption, nephrocalcinosis, nephrolithiasis
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