About this Research Topic
Targeted agents aimed at glioma cells could reduce the impact on other healthy cells, showing more safety and less toxicity than traditional chemotherapeutic drugs. However, molecular mechanisms underlying the targeted therapies for malignant gliomas remain complex due to various influences, including miRNAs, lncRNAs, genetic variances, oncogenes and tumor microenvironment which are involved in modulating tumorigenesis and glioma progression. Molecules that are essential to signaling pathways are potential targets for the treatment of gliomas. Our aim is (1) to provide the latest advancement in the field of targeted therapies for gliomas; (2) to present the experimental and clinical evidence on the effect of targeted agents;(3) to reveal the molecular mechanism underlying the targeted therapies for gliomas.
In this Research Topic, we would like to present the recent advances in novel targeted therapies and the underlying mechanism of gliomas. Preclinical and clinical studies focusing on gliomas, especially glioblastoma, are of particular interest. We welcome Original Research, Reviews, and Methods articles focusing on but not limited to:
1) Novel targeted therapies and new molecules for gliomas treatment;
2) Regulation of signaling pathways and key molecules in gliomas targeted therapies;
3) Animal models and model systems to study novel treatments for gliomas;
4) Identification of predictive diagnostic and prognostic biomarkers in gliomas using proteomics or transcriptomics;
5) Molecular mechanisms of progression, invasion, growth, and survival in gliomas. Manuscripts that are bioinformatics/in silico based without independent clinical validation or functional/experimental validation in vitro and/or in vivo will not be considered.
Keywords: Glioma, Glioblastoma, Targeted Therapy, Molecular Mechanisms, Malignant Tumor, Neuro-oncology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.