Stress is an adaptive, coordinated neurohormonal response that engages central and peripheral systems. This makes pathophysiological dysfunction of stress systems highly debilitating. Still, efficacious pharmacological interventions are lacking. As stress can arise from a multitude of sources (i.e. psychosocial, physical, economic, existential, metabolic, etc,) it is unclear how certain stressors may differentially affect central and peripheral stress systems.
Grip strength is a pre-clinical and clinical assay with strong face validity and predictive power for assessing progression of a host of varied diseases known to impact physiological and cellular stress (i.e. from depression and allodynia, to type-2 diabetes, neurodegeneration, and aging). Recent reports have shown the utility in dynamic grip strength responses in predicting the manifestation of a broad range of pain and stress-related psychopathologies. Due to it’s required engagement of both central and peripheral mechanisms contributing to efferent force production, it is an assay uniquely capable of dissecting central v peripheral mechanisms of pathophysiology. Therefore understanding how stress (of various etiological origins) may impact the physiological mechanisms of grip strength impairment and augmentation of force during grip strength assays may facilitate broad, fruitful advances in therapeutic development to stress-related pathologies at large.
In this Research Topic, we aim to aggregate impactful publications addressing stress-related psychopathologies and their relation to effects on grip strength as well as the recruitment and maintenance of motor units.
Submissions of Original Research, Reviews, and Clinical Trials and welcomed. Techniques may include but are not limited to the following:
Differences in grip strength and/or force flux across preclinical and/or clinical groups with stress or anxiety related psychopathologies
● Real-time in-vivo neurophysiological measures during grip strength in preclinical and/or clinical groups with altered stress physiology
● Clinical and preclinical biomarkers of altered neurohormonal stress responses in relation to grip strength or force profile impairment
● Innovative and comparative exploration of grip strength-related methodologies in clinical/pre-clinical settings
Keywords:
Stress, Anxiety, Pathophysiology, Grip Strength
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Stress is an adaptive, coordinated neurohormonal response that engages central and peripheral systems. This makes pathophysiological dysfunction of stress systems highly debilitating. Still, efficacious pharmacological interventions are lacking. As stress can arise from a multitude of sources (i.e. psychosocial, physical, economic, existential, metabolic, etc,) it is unclear how certain stressors may differentially affect central and peripheral stress systems.
Grip strength is a pre-clinical and clinical assay with strong face validity and predictive power for assessing progression of a host of varied diseases known to impact physiological and cellular stress (i.e. from depression and allodynia, to type-2 diabetes, neurodegeneration, and aging). Recent reports have shown the utility in dynamic grip strength responses in predicting the manifestation of a broad range of pain and stress-related psychopathologies. Due to it’s required engagement of both central and peripheral mechanisms contributing to efferent force production, it is an assay uniquely capable of dissecting central v peripheral mechanisms of pathophysiology. Therefore understanding how stress (of various etiological origins) may impact the physiological mechanisms of grip strength impairment and augmentation of force during grip strength assays may facilitate broad, fruitful advances in therapeutic development to stress-related pathologies at large.
In this Research Topic, we aim to aggregate impactful publications addressing stress-related psychopathologies and their relation to effects on grip strength as well as the recruitment and maintenance of motor units.
Submissions of Original Research, Reviews, and Clinical Trials and welcomed. Techniques may include but are not limited to the following:
Differences in grip strength and/or force flux across preclinical and/or clinical groups with stress or anxiety related psychopathologies
● Real-time in-vivo neurophysiological measures during grip strength in preclinical and/or clinical groups with altered stress physiology
● Clinical and preclinical biomarkers of altered neurohormonal stress responses in relation to grip strength or force profile impairment
● Innovative and comparative exploration of grip strength-related methodologies in clinical/pre-clinical settings
Keywords:
Stress, Anxiety, Pathophysiology, Grip Strength
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.